| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 8/29/2025 | PAT | Max Scherzer | 3R | At | SRD | Kyle Freeland* | 3L | |
| September | 2 | 8/30/2025 | PAT | Eury Perez | 1L | At | SRD | Cade Horton | 3R | |
| September | 3 | 8/31/2025 | PAT | Jose Berrios | 4L | At | SRD | Chris Paddack | E | |
| September | 4 | 9/1/2025 | SRD | Taj Bradley | 1R | At | NYY | Luis Castillo | 6R | |
| September | 5 | 9/2/2025 | SRD | Miles Mikolas | 1L | At | NYY | Braxton Ashcraft | 1R | |
| September | 6 | 9/3/2025 | SRD | A.J. Blubaugh | E | At | NYY | Jack Leiter | 5L | |
| September | OFF | 9/4/2025 | ||||||||
| September | 7 | 9/5/2025 | + | CHI | Randy Vasquez | 2R | At | SRD | Chris Paddack | E |
| September | 8 | 9/6/2025 | + | CHI | Nick Martinez | 2L | At | SRD | Taj Bradley | 1R |
| September | 9 | 9/7/2025 | + | CHI | Dean Kremer | 1R | At | SRD | Miles Mikolas | 1L |
| September | 10 | 9/8/2025 | + | CHI | Janson Junk | 4R | At | SRD | Cade Horton | 3R |
| September | 11 | 9/9/2025 | + | CHI | Noah Cameron* | 2L | At | SRD | Kyle Freeland* | 3L |
| September | 12 | 9/10/2025 | + | SRD | Chris Paddack | E | At | TAM | Grant Holmes | 1L |
| September | 13 | 9/11/2025 | + | SRD | Taj Bradley | 1R | At | TAM | Trevor Rogers* | 1L |
| September | 14 | 9/12/2025 | + | SRD | Miles Mikolas | 1L | At | TAM | Griffin Canning | E |
| September | 15 | 9/13/2025 | + | SRD | Cade Horton | 3R | At | TAM | Brayan Bello | E |
| September | OFF | 9/14/2025 | ||||||||
| September | 16 | 9/15/2025 | + | GGG | Quinn Priester | E | At | SRD | Hayden Wesneski | 4L |
| September | 17 | 9/16/2025 | + | GGG | Stephen Kolek | 1R | At | SRD | Chris Paddack | E |
| September | 18 | 9/17/2025 | + | GGG | Valente Bellozo | 9R | At | SRD | Taj Bradley | 1R |
| September | 19 | 9/18/2025 | + | GGG | Framber Valdez* | 4R | At | SRD | Miles Mikolas | 1L |
| September | 20 | 9/19/2025 | + | GGG | Eric Lauer* | 1L | At | SRD | Cade Horton | 3R |
| September | 21 | 9/20/2025 | + | SRD | Kyle Freeland* | 3L | At | DYE | Kolby Allard* | 2R |
| September | 22 | 9/21/2025 | + | SRD | Chris Paddack | E | At | DYE | Robbie Ray* | 3L |
| September | 23 | 9/22/2025 | + | SRD | Chris Sale* | 3L | At | DYE | Ryan Pepiot | 3L |
| September | 24 | 9/23/2025 | + | SRD | Miles Mikolas | 1L | At | DYE | Bryan Woo | E |
| + Indicates In Division Game | ||||||||||