| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| June | 1 | 6/8/2025 | SRD | Miles Mikolas | 1L | At | CRC | Garrett Crochet* | 5L | |
| June | 2 | 6/9/2025 | SRD | Kyle Freeland* | 3L | At | CRC | Kevin Gausman | 3L | |
| June | 3 | 6/10/2025 | SRD | Cade Horton | 3R | At | CRC | Tanner Bibee | 1L | |
| June | 4 | 6/11/2025 | TEX | Max Fried* | 2R | At | SRD | Chris Sale* | 3L | |
| June | 5 | 6/12/2025 | TEX | Nick Lodolo* | 5R | At | SRD | Chris Paddack | E | |
| June | 6 | 6/13/2025 | TEX | Chad Patrick | 1R | At | SRD | Taj Bradley | 1R | |
| June | OFF | 6/14/2025 | ||||||||
| June | 7 | 6/15/2025 | HMA | Carmen Mlodzinski | 3L | At | SRD | Miles Mikolas | 1L | |
| June | 8 | 6/16/2025 | HMA | Jesus Luzardo* | 5L | At | SRD | Kyle Freeland* | 3L | |
| June | 9 | 6/17/2025 | HMA | Jacob Degrom | 2L | At | SRD | Cade Horton | 3R | |
| June | 10 | 6/18/2025 | SRD | Chris Sale* | 3L | At | CUB | Kodai Senga | 2R | |
| June | 11 | 6/19/2025 | SRD | Chris Paddack | E | At | CUB | Yoshinobu Yamamoto | 3L | |
| June | 12 | 6/20/2025 | SRD | Taj Bradley | 1R | At | CUB | Mackenzie Gore* | 2L | |
| June | 13 | 6/21/2025 | SRD | Miles Mikolas | 1L | At | NIM | Jeffrey Springs* | 1L | |
| June | 14 | 6/22/2025 | SRD | Kyle Freeland* | 3L | At | NIM | Matt Boyd* | 3L | |
| June | 15 | 6/23/2025 | SRD | Cade Horton | 3R | At | NIM | Dylan Cease | E | |
| June | OFF | 6/24/2025 | ||||||||
| June | 16 | 6/25/2025 | + | TAM | Zack Wheeler | E | At | SRD | Chris Sale* | 3L |
| June | 17 | 6/26/2025 | + | TAM | Kyle Bradish | 6R | At | SRD | Chris Paddack | E |
| June | 18 | 6/27/2025 | + | TAM | Hunter Brown | E | At | SRD | Taj Bradley | 1R |
| June | 19 | 6/28/2025 | + | TAM | Trevor Rogers* | 1L | At | SRD | Miles Mikolas | 1L |
| June | 20 | 6/29/2025 | + | TAM | Brayan Bello | E | At | SRD | Kyle Freeland* | 3L |
| June | 21 | 6/30/2025 | + | SRD | Cade Horton | 3R | At | CHI | Dean Kremer | 1R |
| June | 22 | 7/1/2025 | + | SRD | Chris Sale* | 3L | At | CHI | Randy Vasquez | 2R |
| June | 23 | 7/2/2025 | + | SRD | Chris Paddack | E | At | CHI | Noah Cameron* | 2L |
| June | 24 | 7/3/2025 | + | SRD | Taj Bradley | 1R | At | CHI | Nick Martinez | 2L |
| + Indicates In Division Game | ||||||||||