| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| June | 1 | 6/8/2025 | CHI | Janson Junk | 4R | At | CUB | Yoshinobu Yamamoto | 3L | |
| June | 2 | 6/9/2025 | CHI | Randy Vasquez | 2R | At | CUB | Mackenzie Gore* | 2L | |
| June | 3 | 6/10/2025 | CHI | Dean Kremer | 1R | At | CUB | Kyle Hendricks | 4L | |
| June | 4 | 6/11/2025 | CUB | Jake Irvin | 4R | At | HUC | Joe Ryan | 5R | |
| June | 5 | 6/12/2025 | CUB | Kodai Senga | 2R | At | HUC | Blake Snell* | 1R | |
| June | 6 | 6/13/2025 | CUB | Yoshinobu Yamamoto | 3L | At | HUC | Pablo Lopez | 3R | |
| June | OFF | 6/14/2025 | ||||||||
| June | 7 | 6/15/2025 | CUB | Mackenzie Gore* | 2L | At | NIM | Kris Bubic* | 1R | |
| June | 8 | 6/16/2025 | CUB | Kyle Hendricks | 4L | At | NIM | Jeffrey Springs* | 1L | |
| June | 9 | 6/17/2025 | CUB | Jake Irvin | 4R | At | NIM | Matt Boyd* | 3L | |
| June | 10 | 6/18/2025 | SRD | Chris Sale* | 3L | At | CUB | Kodai Senga | 2R | |
| June | 11 | 6/19/2025 | SRD | Chris Paddack | E | At | CUB | Yoshinobu Yamamoto | 3L | |
| June | 12 | 6/20/2025 | SRD | Taj Bradley | 1R | At | CUB | Mackenzie Gore* | 2L | |
| June | 13 | 6/21/2025 | CUB | Kyle Hendricks | 4L | At | HMA | Jesus Luzardo* | 5L | |
| June | 14 | 6/22/2025 | CUB | Jake Irvin | 4R | At | HMA | Jacob Degrom | 2L | |
| June | 15 | 6/23/2025 | CUB | Kodai Senga | 2R | At | HMA | Carlos Rodon* | E | |
| June | OFF | 6/24/2025 | ||||||||
| June | 16 | 6/25/2025 | + | DUB | Zebby Matthews | 7R | At | CUB | Yoshinobu Yamamoto | 3L |
| June | 17 | 6/26/2025 | + | DUB | Mitch Keller | 4R | At | CUB | Mackenzie Gore* | 2L |
| June | 18 | 6/27/2025 | + | DUB | David Peterson* | 4L | At | CUB | Kyle Hendricks | 4L |
| June | 19 | 6/28/2025 | + | DUB | Matthew Liberatore* | 1R | At | CUB | Jake Irvin | 4R |
| June | 20 | 6/29/2025 | + | DUB | Jose Quintana* | 1R | At | CUB | Kodai Senga | 2R |
| June | 21 | 6/30/2025 | + | CUB | Yoshinobu Yamamoto | 3L | At | CRC | Tanner Bibee | 1L |
| June | 22 | 7/1/2025 | + | CUB | Mackenzie Gore* | 2L | At | CRC | Sonny Gray | 5L |
| June | 23 | 7/2/2025 | + | CUB | Kyle Hendricks | 4L | At | CRC | Michael Wacha | 2L |
| June | 24 | 7/3/2025 | + | CUB | Jake Irvin | 4R | At | CRC | Logan Gilbert | 3L |
| + Indicates In Division Game | ||||||||||