| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| June | 1 | 6/8/2025 | SRD | Miles Mikolas | 1L | At | CRC | Garrett Crochet* | 5L | |
| June | 2 | 6/9/2025 | SRD | Kyle Freeland* | 3L | At | CRC | Kevin Gausman | 3L | |
| June | 3 | 6/10/2025 | SRD | Cade Horton | 3R | At | CRC | Tanner Bibee | 1L | |
| June | 4 | 6/11/2025 | NIM | Dylan Cease | E | At | CRC | Sonny Gray | 5L | |
| June | 5 | 6/12/2025 | NIM | Matt Boyd* | 3L | At | CRC | Michael Wacha | 2L | |
| June | 6 | 6/13/2025 | NIM | Keider Montero | 5R | At | CRC | Logan Gilbert | 3L | |
| June | OFF | 6/14/2025 | ||||||||
| June | 7 | 6/15/2025 | + | CRC | Garrett Crochet* | 5L | At | DUB | Matthew Liberatore* | 1R |
| June | 8 | 6/16/2025 | + | CRC | Kevin Gausman | 3L | At | DUB | Jose Quintana* | 1R |
| June | 9 | 6/17/2025 | + | CRC | Tanner Bibee | 1L | At | DUB | Andrew Abbott* | E |
| June | 10 | 6/18/2025 | + | CRC | Sonny Gray | 5L | At | DUB | Zebby Matthews | 7R |
| June | 11 | 6/19/2025 | + | CRC | Michael Wacha | 2L | At | DUB | Mitch Keller | 4R |
| June | 12 | 6/20/2025 | + | PAT | Ryne Nelson | 6L | At | CRC | Logan Gilbert | 3L |
| June | 13 | 6/21/2025 | + | PAT | Shane Smith | 4R | At | CRC | Garrett Crochet* | 5L |
| June | 14 | 6/22/2025 | + | PAT | Eury Perez | 1L | At | CRC | Kevin Gausman | 3L |
| June | 15 | 6/23/2025 | + | PAT | Jose Berrios | 4L | At | CRC | Tanner Bibee | 1L |
| June | OFF | 6/24/2025 | ||||||||
| June | 16 | 6/25/2025 | + | CRC | Sonny Gray | 5L | At | BUR | Lucas Giolito | 1L |
| June | 17 | 6/26/2025 | + | CRC | Michael Wacha | 2L | At | BUR | Brady Singer | 4R |
| June | 18 | 6/27/2025 | + | CRC | Logan Gilbert | 3L | At | BUR | J.P. Sears* | 1L |
| June | 19 | 6/28/2025 | + | CRC | Garrett Crochet* | 5L | At | BUR | Justin Verlander | 1L |
| June | 20 | 6/29/2025 | + | CRC | Kevin Gausman | 3L | At | BUR | Luis Severino | 2R |
| June | 21 | 6/30/2025 | + | CUB | Yoshinobu Yamamoto | 3L | At | CRC | Tanner Bibee | 1L |
| June | 22 | 7/1/2025 | + | CUB | Mackenzie Gore* | 2L | At | CRC | Sonny Gray | 5L |
| June | 23 | 7/2/2025 | + | CUB | Kyle Hendricks | 4L | At | CRC | Michael Wacha | 2L |
| June | 24 | 7/3/2025 | + | CUB | Jake Irvin | 4R | At | CRC | Logan Gilbert | 3L |
| + Indicates In Division Game | ||||||||||