| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| June | 1 | 6/8/2025 | NYY | Luis Castillo | 6R | At | COL | Tyler Glasnow | E | |
| June | 2 | 6/9/2025 | NYY | Jack Leiter | 5L | At | COL | Brandon Woodruff | 4L | |
| June | 3 | 6/10/2025 | NYY | Nick Pivetta | 3L | At | COL | Tarik Skubal* | E | |
| June | 4 | 6/11/2025 | COL | Zac Gallen | E | At | BUR | Justin Verlander | 1L | |
| June | 5 | 6/12/2025 | COL | Freddy Peralta | E | At | BUR | Luis Severino | 2R | |
| June | 6 | 6/13/2025 | COL | Shawn Armstrong | 9R | At | BUR | Lucas Giolito | 1L | |
| June | OFF | 6/14/2025 | ||||||||
| June | 7 | 6/15/2025 | + | WRK | Luis Ortiz | 2R | At | COL | Tyler Holton* | 8L |
| June | 8 | 6/16/2025 | + | WRK | Cristopher Sanchez* | 4L | At | COL | Tyler Glasnow | E |
| June | 9 | 6/17/2025 | + | WRK | Michael McGreevy | 9R | At | COL | Brandon Woodruff | 4L |
| June | 10 | 6/18/2025 | + | WRK | Casey Mize | 1L | At | COL | Tarik Skubal* | E |
| June | 11 | 6/19/2025 | + | WRK | Spencer Strider | E | At | COL | Freddy Peralta | E |
| June | 12 | 6/20/2025 | + | COL | Zac Gallen | E | At | HUC | Chris Bassitt | 4R |
| June | 13 | 6/21/2025 | + | COL | Huascar Brazoban | 9R | At | HUC | Joe Ryan | 5R |
| June | 14 | 6/22/2025 | + | COL | J.T. Ginn | 9R | At | HUC | Blake Snell* | 1R |
| June | 15 | 6/23/2025 | + | COL | Tarik Skubal* | E | At | HUC | Pablo Lopez | 3R |
| June | OFF | 6/24/2025 | ||||||||
| June | 16 | 6/25/2025 | PAT | Shane Baz | 2L | At | COL | Freddy Peralta | E | |
| June | 17 | 6/26/2025 | PAT | Ryne Nelson | 6L | At | COL | Tyler Glasnow | E | |
| June | 18 | 6/27/2025 | PAT | Shane Smith | 4R | At | COL | Zac Gallen | E | |
| June | 19 | 6/28/2025 | COL | Tarik Skubal* | E | At | AAR | Zack Littell | 1L | |
| June | 20 | 6/29/2025 | COL | Brandon Woodruff | 4L | At | AAR | Seth Lugo | 7R | |
| June | 21 | 6/30/2025 | COL | Freddy Peralta | E | At | AAR | Paul Skenes | 2R | |
| June | 22 | 7/1/2025 | DYE | Robbie Ray* | 3L | At | COL | Tyler Glasnow | E | |
| June | 23 | 7/2/2025 | DYE | Ryan Pepiot | 3L | At | COL | Zac Gallen | E | |
| June | 24 | 7/3/2025 | DYE | Bryan Woo | E | At | COL | Tarik Skubal* | E | |
| + Indicates In Division Game | ||||||||||