| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| May | 1 | 5/12/2025 | SRD | Kyle Freeland* | 3L | At | AAR | Paul Skenes | 2R | |
| May | 2 | 5/13/2025 | SRD | Robbie Ray* | 3L | At | AAR | Slade Cecconi | 3L | |
| May | 3 | 5/14/2025 | SRD | Chris Sale* | 3L | At | AAR | Clarke Schmidt | 5R | |
| May | OFF | 5/15/2025 | ||||||||
| May | 4 | 5/16/2025 | + | SRD | Chris Paddack | E | At | TAM | Brayan Bello | E |
| May | 5 | 5/17/2025 | + | SRD | Yu Darvish | 5R | At | TAM | Griffin Canning | E |
| May | 6 | 5/18/2025 | + | SRD | Taj Bradley | 1R | At | TAM | Trevor Rogers* | 1L |
| May | 7 | 5/19/2025 | + | SRD | Kyle Freeland* | 3L | At | TAM | Michael King | 1R |
| May | 8 | 5/20/2025 | + | SRD | Robbie Ray* | 3L | At | TAM | Joey Cantillo* | 5R |
| May | 9 | 5/21/2025 | + | GGG | Dustin May | 3R | At | SRD | Chris Sale* | 3L |
| May | 10 | 5/22/2025 | + | GGG | Jack Flaherty | 2R | At | SRD | Chris Paddack | E |
| May | 11 | 5/23/2025 | + | GGG | Logan Evans | E | At | SRD | Yu Darvish | 5R |
| May | 12 | 5/24/2025 | + | GGG | Stephen Kolek | 1R | At | SRD | Taj Bradley | 1R |
| May | OFF | 5/25/2025 | ||||||||
| May | 13 | 5/26/2025 | + | SRD | Kyle Freeland* | 3L | At | DYE | Bryan Woo | E |
| May | 14 | 5/27/2025 | + | SRD | Robbie Ray* | 3L | At | DYE | Ryan Bergert | E |
| May | 15 | 5/28/2025 | + | SRD | Chris Sale* | 3L | At | DYE | Jose Soriano | 2L |
| May | 16 | 5/29/2025 | + | SRD | Chris Paddack | E | At | DYE | Ryan Pepiot | 3L |
| May | 17 | 5/30/2025 | + | SRD | Yu Darvish | 5R | At | DYE | Kolby Allard* | 2R |
| May | 18 | 5/31/2025 | + | CHI | Dean Kremer | 1R | At | SRD | Taj Bradley | 1R |
| May | 19 | 6/1/2025 | + | CHI | Noah Cameron* | 2L | At | SRD | Kyle Freeland* | 3L |
| May | 20 | 6/2/2025 | + | CHI | Spencer Schwellenbach | 3R | At | SRD | Robbie Ray* | 3L |
| May | 21 | 6/3/2025 | + | CHI | Randy Vasquez | 2R | At | SRD | Chris Sale* | 3L |
| May | OFF | 6/4/2025 | ||||||||
| May | 22 | 6/5/2025 | HUC | Chris Bassitt | 4R | At | SRD | Chris Paddack | E | |
| May | 23 | 6/6/2025 | HUC | Joe Ryan | 5R | At | SRD | Yu Darvish | 5R | |
| May | 24 | 6/7/2025 | HUC | Cole Ragans* | 1R | At | SRD | Taj Bradley | 1R | |
| + Indicates In Division Game | ||||||||||