| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| May | 1 | 5/12/2025 | GGG | Eric Lauer* | 1L | At | HMA | Merrill Kelly | 1R | |
| May | 2 | 5/13/2025 | GGG | Logan Evans | E | At | HMA | Jesus Luzardo* | 5L | |
| May | 3 | 5/14/2025 | GGG | Jack Flaherty | 2R | At | HMA | Jacob Degrom | 2L | |
| May | OFF | 5/15/2025 | ||||||||
| May | 4 | 5/16/2025 | + | HMA | Carlos Rodon* | E | At | NYY | Nick Pivetta | 3L |
| May | 5 | 5/17/2025 | + | HMA | Nathan Eovaldi | 2R | At | NYY | Clay Holmes | 1L |
| May | 6 | 5/18/2025 | + | HMA | Merrill Kelly | 1R | At | NYY | Ranger Suarez* | 2L |
| May | 7 | 5/19/2025 | + | HMA | Jesus Luzardo* | 5L | At | NYY | Luis Castillo | 6R |
| May | 8 | 5/20/2025 | + | HMA | Jacob Degrom | 2L | At | NYY | Jack Leiter | 5L |
| May | 9 | 5/21/2025 | + | BZZ | Logan Webb | 3R | At | HMA | Carlos Rodon* | E |
| May | 10 | 5/22/2025 | + | BZZ | Tyler Glasnow | E | At | HMA | Nathan Eovaldi | 2R |
| May | 11 | 5/23/2025 | + | BZZ | Tyler Mahle | 5L | At | HMA | Merrill Kelly | 1R |
| May | 12 | 5/24/2025 | + | BZZ | Tomoyuki Sugano | 1R | At | HMA | Jesus Luzardo* | 5L |
| May | OFF | 5/25/2025 | ||||||||
| May | 13 | 5/26/2025 | + | HMA | Jacob Degrom | 2L | At | AAR | Shohei Ohtani | 8L |
| May | 14 | 5/27/2025 | + | HMA | Carlos Rodon* | E | At | AAR | Zack Littell | 1L |
| May | 15 | 5/28/2025 | + | HMA | Nathan Eovaldi | 2R | At | AAR | Gavin Williams | 3L |
| May | 16 | 5/29/2025 | + | HMA | Merrill Kelly | 1R | At | AAR | Paul Skenes | 2R |
| May | 17 | 5/30/2025 | + | HMA | Jesus Luzardo* | 5L | At | AAR | Slade Cecconi | 3L |
| May | 18 | 5/31/2025 | + | TEX | Max Fried* | 2R | At | HMA | Jacob Degrom | 2L |
| May | 19 | 6/1/2025 | + | TEX | Nick Lodolo* | 5R | At | HMA | Carlos Rodon* | E |
| May | 20 | 6/2/2025 | + | TEX | Hunter Brown | E | At | HMA | Nathan Eovaldi | 2R |
| May | 21 | 6/3/2025 | + | TEX | Bailey Ober | 1L | At | HMA | Merrill Kelly | 1R |
| May | OFF | 6/4/2025 | ||||||||
| May | 22 | 6/5/2025 | CRC | Sonny Gray | 5L | At | HMA | Jesus Luzardo* | 5L | |
| May | 23 | 6/6/2025 | CRC | Michael Wacha | 2L | At | HMA | Jacob Degrom | 2L | |
| May | 24 | 6/7/2025 | CRC | Logan Gilbert | 3L | At | HMA | Carlos Rodon* | E | |
| + Indicates In Division Game | ||||||||||