| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| May | 1 | 5/12/2025 | CUB | Yoshinobu Yamamoto | 3L | At | COL | Tarik Skubal* | E | |
| May | 2 | 5/13/2025 | CUB | Hunter Greene | 1L | At | COL | Roki Sasaki | 1L | |
| May | 3 | 5/14/2025 | CUB | Edward Cabrera | 1R | At | COL | Emmet Sheehan | 2L | |
| May | OFF | 5/15/2025 | ||||||||
| May | 4 | 5/16/2025 | + | CUB | Kodai Senga | 2R | At | DUB | Jackson Jobe | 3L |
| May | 5 | 5/17/2025 | + | CUB | Mackenzie Gore* | 2L | At | DUB | Mitch Keller | 4R |
| May | 6 | 5/18/2025 | + | CUB | Yoshinobu Yamamoto | 3L | At | DUB | David Peterson* | 4L |
| May | 7 | 5/19/2025 | + | CUB | Hunter Greene | 1L | At | DUB | Matthew Liberatore* | 1R |
| May | 8 | 5/20/2025 | + | CUB | Edward Cabrera | 1R | At | DUB | Jose Quintana* | 1R |
| May | 9 | 5/21/2025 | + | BUR | Bailey Falter* | 1R | At | CUB | Kodai Senga | 2R |
| May | 10 | 5/22/2025 | + | BUR | J.P. Sears* | 1L | At | CUB | Mackenzie Gore* | 2L |
| May | 11 | 5/23/2025 | + | BUR | Justin Verlander | 1L | At | CUB | Yoshinobu Yamamoto | 3L |
| May | 12 | 5/24/2025 | + | BUR | Luis Severino | 2R | At | CUB | Hunter Greene | 1L |
| May | OFF | 5/25/2025 | ||||||||
| May | 13 | 5/26/2025 | + | CUB | Edward Cabrera | 1R | At | PAT | Simeon Woods-Richard | 1L |
| May | 14 | 5/27/2025 | + | CUB | Kodai Senga | 2R | At | PAT | Jose Berrios | 4L |
| May | 15 | 5/28/2025 | + | CUB | Mackenzie Gore* | 2L | At | PAT | Shane Baz | 2L |
| May | 16 | 5/29/2025 | + | CUB | Yoshinobu Yamamoto | 3L | At | PAT | Ryne Nelson | 6L |
| May | 17 | 5/30/2025 | + | CUB | Hunter Greene | 1L | At | PAT | Shane Smith | 4R |
| May | 18 | 5/31/2025 | + | CRC | Logan Gilbert | 3L | At | CUB | Edward Cabrera | 1R |
| May | 19 | 6/1/2025 | + | CRC | Garrett Crochet* | 5L | At | CUB | Kodai Senga | 2R |
| May | 20 | 6/2/2025 | + | CRC | Kevin Gausman | 3L | At | CUB | Mackenzie Gore* | 2L |
| May | 21 | 6/3/2025 | + | CRC | Tanner Bibee | 1L | At | CUB | Yoshinobu Yamamoto | 3L |
| May | OFF | 6/4/2025 | ||||||||
| May | 22 | 6/5/2025 | TEX | Bryce Elder | 6L | At | CUB | Hunter Greene | 1L | |
| May | 23 | 6/6/2025 | TEX | Max Fried* | 2R | At | CUB | Edward Cabrera | 1R | |
| May | 24 | 6/7/2025 | TEX | Nick Lodolo* | 5R | At | CUB | Kodai Senga | 2R | |
| + Indicates In Division Game | ||||||||||