| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| May | 1 | 5/12/2025 | CUB | Yoshinobu Yamamoto | 3L | At | COL | Tarik Skubal* | E | |
| May | 2 | 5/13/2025 | CUB | Hunter Greene | 1L | At | COL | Roki Sasaki | 1L | |
| May | 3 | 5/14/2025 | CUB | Edward Cabrera | 1R | At | COL | Emmet Sheehan | 2L | |
| May | OFF | 5/15/2025 | ||||||||
| May | 4 | 5/16/2025 | + | COL | Shawn Armstrong | 9R | At | WRK | Cristopher Sanchez* | 4L |
| May | 5 | 5/17/2025 | + | COL | Freddy Peralta | E | At | WRK | Zack Wheeler | E |
| May | 6 | 5/18/2025 | + | COL | Tarik Skubal* | E | At | WRK | Spencer Strider | E |
| May | 7 | 5/19/2025 | + | COL | Roki Sasaki | 1L | At | WRK | Casey Mize | 1L |
| May | 8 | 5/20/2025 | + | COL | Emmet Sheehan | 2L | At | WRK | Luis Ortiz | 2R |
| May | 9 | 5/21/2025 | + | VRN | Patrick Corbin* | 2L | At | COL | Zac Gallen | E |
| May | 10 | 5/22/2025 | + | VRN | Chase Dollander | 4R | At | COL | Freddy Peralta | E |
| May | 11 | 5/23/2025 | + | VRN | Will Warren | 2R | At | COL | Tarik Skubal* | E |
| May | 12 | 5/24/2025 | + | VRN | Sandy Alcantara | 1L | At | COL | Roki Sasaki | 1L |
| May | OFF | 5/25/2025 | ||||||||
| May | 13 | 5/26/2025 | + | NIM | Jameson Taillon | 7L | At | COL | Emmet Sheehan | 2L |
| May | 14 | 5/27/2025 | + | NIM | Matt Boyd* | 3L | At | COL | Zac Gallen | E |
| May | 15 | 5/28/2025 | + | NIM | Dylan Cease | E | At | COL | Freddy Peralta | E |
| May | 16 | 5/29/2025 | + | NIM | Kris Bubic* | 1R | At | COL | Tarik Skubal* | E |
| May | 17 | 5/30/2025 | + | NIM | Jeffrey Springs* | 1L | At | COL | Roki Sasaki | 1L |
| May | 18 | 5/31/2025 | + | COL | Emmet Sheehan | 2L | At | VRN | Patrick Corbin* | 2L |
| May | 19 | 6/1/2025 | + | COL | Zac Gallen | E | At | VRN | Chase Dollander | 4R |
| May | 20 | 6/2/2025 | + | COL | Freddy Peralta | E | At | VRN | Will Warren | 2R |
| May | 21 | 6/3/2025 | + | COL | Tarik Skubal* | E | At | VRN | Sandy Alcantara | 1L |
| May | OFF | 6/4/2025 | ||||||||
| May | 22 | 6/5/2025 | COL | Shawn Armstrong | 9R | At | GGG | Stephen Kolek | 1R | |
| May | 23 | 6/6/2025 | COL | Zac Gallen | E | At | GGG | Framber Valdez* | 4R | |
| May | 24 | 6/7/2025 | COL | Freddy Peralta | E | At | GGG | Eric Lauer* | 1L | |
| + Indicates In Division Game | ||||||||||