| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| April | 1 | 4/19/2025 | CHI | Randy Vasquez | 2R | At | PAT | Shane Baz | 2L | |
| April | 2 | 4/20/2025 | CHI | Andrew Alvarez* | 6R | At | PAT | Ryne Nelson | 6L | |
| April | 3 | 4/21/2025 | CHI | Nick Martinez | 2L | At | PAT | Shane Smith | 4R | |
| April | OFF | 4/22/2025 | ||||||||
| April | 4 | 4/23/2025 | HUC | Joe Ryan | 5R | At | PAT | Simeon Woods-Richard | 1L | |
| April | 5 | 4/24/2025 | HUC | Cole Ragans* | 1R | At | PAT | Jose Berrios | 4L | |
| April | 6 | 4/25/2025 | HUC | Chris Bassitt | 4R | At | PAT | Shane Baz | 2L | |
| April | 7 | 4/26/2025 | PAT | Ryne Nelson | 6L | At | NYY | Nick Pivetta | 3L | |
| April | 8 | 4/27/2025 | PAT | Shane Smith | 4R | At | NYY | Jack Leiter | 5L | |
| April | 9 | 4/28/2025 | PAT | Simeon Woods-Richard | 1L | At | NYY | Corbin Burnes | 2L | |
| April | 10 | 4/29/2025 | SRD | Kyle Freeland* | 3L | At | PAT | Jose Berrios | 4L | |
| April | 11 | 4/30/2025 | SRD | Robbie Ray* | 3L | At | PAT | Shane Baz | 2L | |
| April | 12 | 5/1/2025 | SRD | Chris Sale* | 3L | At | PAT | Ryne Nelson | 6L | |
| April | OFF | 5/2/2025 | ||||||||
| April | 13 | 5/3/2025 | PAT | Shane Smith | 4R | At | NIM | Brad Lord | 5R | |
| April | 14 | 5/4/2025 | PAT | Simeon Woods-Richard | 1L | At | NIM | Keider Montero | 5R | |
| April | 15 | 5/5/2025 | PAT | Jose Berrios | 4L | At | NIM | Matt Boyd* | 3L | |
| April | 16 | 5/6/2025 | HMA | Nathan Eovaldi | 2R | At | PAT | Shane Baz | 2L | |
| April | 17 | 5/7/2025 | HMA | Merrill Kelly | 1R | At | PAT | Ryne Nelson | 6L | |
| April | 18 | 5/8/2025 | HMA | Jesus Luzardo* | 5L | At | PAT | Shane Smith | 4R | |
| April | 19 | 5/9/2025 | PAT | Simeon Woods-Richard | 1L | At | GGG | Michael Lorenzen | 1L | |
| April | 20 | 5/10/2025 | PAT | Jose Berrios | 4L | At | GGG | Dustin May | 3R | |
| April | 21 | 5/11/2025 | PAT | Shane Baz | 2L | At | GGG | Framber Valdez* | 4R | |
| + Indicates In Division Game | ||||||||||