| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| April | 1 | 4/19/2025 | GGG | Framber Valdez* | 4R | At | CUB | Jake Irvin | 4R | |
| April | 2 | 4/20/2025 | GGG | Stephen Kolek | 1R | At | CUB | Kodai Senga | 2R | |
| April | 3 | 4/21/2025 | GGG | Logan Evans | E | At | CUB | Edward Cabrera | 1R | |
| April | OFF | 4/22/2025 | ||||||||
| April | 4 | 4/23/2025 | NYY | Corbin Burnes | 2L | At | GGG | Dustin May | 3R | |
| April | 5 | 4/24/2025 | NYY | Braxton Ashcraft | 1R | At | GGG | Jack Flaherty | 2R | |
| April | 6 | 4/25/2025 | NYY | Clay Holmes | 1L | At | GGG | Framber Valdez* | 4R | |
| April | 7 | 4/26/2025 | GGG | Michael Lorenzen | 1L | At | HUC | Johan Oviedo | 1L | |
| April | 8 | 4/27/2025 | GGG | Logan Evans | E | At | HUC | Drew Rasmussen | 3R | |
| April | 9 | 4/28/2025 | GGG | Dustin May | 3R | At | HUC | Joe Ryan | 5R | |
| April | 10 | 4/29/2025 | CRC | Garrett Crochet* | 5L | At | GGG | Stephen Kolek | 1R | |
| April | 11 | 4/30/2025 | CRC | Kevin Gausman | 3L | At | GGG | Jack Flaherty | 2R | |
| April | 12 | 5/1/2025 | CRC | Tanner Bibee | 1L | At | GGG | Michael Lorenzen | 1L | |
| April | OFF | 5/2/2025 | ||||||||
| April | 13 | 5/3/2025 | GGG | Logan Evans | E | At | TEX | Max Fried* | 2R | |
| April | 14 | 5/4/2025 | GGG | Dustin May | 3R | At | TEX | Logan Henderson | 2R | |
| April | 15 | 5/5/2025 | GGG | Stephen Kolek | 1R | At | TEX | Brandon Sproat | 5R | |
| April | 16 | 5/6/2025 | GGG | Framber Valdez* | 4R | At | NIM | Dylan Cease | E | |
| April | 17 | 5/7/2025 | GGG | Jack Flaherty | 2R | At | NIM | Jeffrey Springs* | 1L | |
| April | 18 | 5/8/2025 | GGG | Logan Evans | E | At | NIM | Brad Lord | 5R | |
| April | 19 | 5/9/2025 | PAT | Simeon Woods-Richard | 1L | At | GGG | Michael Lorenzen | 1L | |
| April | 20 | 5/10/2025 | PAT | Jose Berrios | 4L | At | GGG | Dustin May | 3R | |
| April | 21 | 5/11/2025 | PAT | Shane Baz | 2L | At | GGG | Framber Valdez* | 4R | |
| + Indicates In Division Game | ||||||||||