| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| April | 1 | 4/19/2025 | TEX | Hunter Brown | E | At | COL | Troy Melton | 3R | |
| April | 2 | 4/20/2025 | TEX | Nick Lodolo* | 5R | At | COL | Ronel Blanco | 7R | |
| April | 3 | 4/21/2025 | TEX | Max Fried* | 2R | At | COL | Tarik Skubal* | E | |
| April | OFF | 4/22/2025 | ||||||||
| April | 4 | 4/23/2025 | COL | Shawn Armstrong | 9R | At | CRC | Garrett Crochet* | 5L | |
| April | 5 | 4/24/2025 | COL | Freddy Peralta | E | At | CRC | Kevin Gausman | 3L | |
| April | 6 | 4/25/2025 | COL | Ronel Blanco | 7R | At | CRC | Tanner Bibee | 1L | |
| April | 7 | 4/26/2025 | TAM | Joey Cantillo* | 5R | At | COL | Zac Gallen | E | |
| April | 8 | 4/27/2025 | TAM | Cam Schlittler | 1L | At | COL | Troy Melton | 3R | |
| April | 9 | 4/28/2025 | TAM | Chad Patrick | 1R | At | COL | Tarik Skubal* | E | |
| April | 10 | 4/29/2025 | HMA | Carlos Rodon* | E | At | COL | Freddy Peralta | E | |
| April | 11 | 4/30/2025 | HMA | Nathan Eovaldi | 2R | At | COL | Ronel Blanco | 7R | |
| April | 12 | 5/1/2025 | HMA | Merrill Kelly | 1R | At | COL | Zac Gallen | E | |
| April | OFF | 5/2/2025 | ||||||||
| April | 13 | 5/3/2025 | COL | Shawn Armstrong | 9R | At | DUB | Zebby Matthews | 7R | |
| April | 14 | 5/4/2025 | COL | Troy Melton | 3R | At | DUB | Mitch Keller | 4R | |
| April | 15 | 5/5/2025 | COL | Tarik Skubal* | E | At | DUB | David Peterson* | 4L | |
| April | 16 | 5/6/2025 | SRD | Kyle Freeland* | 3L | At | COL | Ronel Blanco | 7R | |
| April | 17 | 5/7/2025 | SRD | Robbie Ray* | 3L | At | COL | Freddy Peralta | E | |
| April | 18 | 5/8/2025 | SRD | Chris Sale* | 3L | At | COL | Huascar Brazoban | 9R | |
| April | 19 | 5/9/2025 | COL | Zac Gallen | E | At | BZZ | Adrian Houser | 4R | |
| April | 20 | 5/10/2025 | COL | Troy Melton | 3R | At | BZZ | Shota Imanaga* | 2L | |
| April | 21 | 5/11/2025 | COL | Ronel Blanco | 7R | At | BZZ | Logan Webb | 3R | |
| + Indicates In Division Game | ||||||||||