| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| May | 1 | 5/12/2024 | HMA | Jesus Luzardo* | 1R | At | COL | Tarik Skubal* | 2L | |
| May | 2 | 5/13/2024 | HMA | Mitch Keller | 3R | At | COL | Justin Steele* | 3L | |
| May | 3 | 5/14/2024 | HMA | Jared Jones | E | At | COL | Ranger Suarez* | 3R | |
| May | OFF | 5/15/2024 | ||||||||
| May | 4 | 5/16/2024 | + | COL | Zac Gallen | 2L | At | NIM | Dylan Cease | 3R |
| May | 5 | 5/17/2024 | + | COL | Erick Fedde | 1R | At | NIM | Jeffrey Springs* | 1L |
| May | 6 | 5/18/2024 | + | COL | Tarik Skubal* | 2L | At | NIM | Jameson Taillon | 3R |
| May | 7 | 5/19/2024 | + | COL | Freddy Peralta | 5L | At | NIM | Ben Lively | 1L |
| May | 8 | 5/20/2024 | + | COL | Justin Steele* | 3L | At | NIM | Jake Irvin | 2R |
| May | 9 | 5/21/2024 | + | WRK | Cristopher Sanchez* | 1L | At | COL | Ranger Suarez* | 3R |
| May | 10 | 5/22/2024 | + | WRK | Casey Mize | 2L | At | COL | Zac Gallen | 2L |
| May | 11 | 5/23/2024 | + | WRK | Matt Waldron | 1R | At | COL | Erick Fedde | 1R |
| May | 12 | 5/24/2024 | + | WRK | Alec Marsh | 1L | At | COL | Tarik Skubal* | 2L |
| May | OFF | 5/25/2024 | ||||||||
| May | 13 | 5/26/2024 | + | COL | Freddy Peralta | 5L | At | VRN | Patrick Corbin* | 7L |
| May | 14 | 5/27/2024 | + | COL | Justin Steele* | 3L | At | VRN | Dean Kremer | 2R |
| May | 15 | 5/28/2024 | + | COL | Ranger Suarez* | 3R | At | VRN | Yariel Rodriguez | E |
| May | 16 | 5/29/2024 | + | COL | Tarik Skubal* | 2L | At | VRN | Zach Eflin | 4L |
| May | 17 | 5/30/2024 | + | COL | Zac Gallen | 2L | At | VRN | Spencer Arrighetti | 2L |
| May | 18 | 5/31/2024 | + | HUC | Hogan Harris* | 5R | At | COL | Erick Fedde | 1R |
| May | 19 | 6/1/2024 | + | HUC | Blake Snell* | 1L | At | COL | Freddy Peralta | 5L |
| May | 20 | 6/2/2024 | + | HUC | Reese Olson | 3R | At | COL | Justin Steele* | 3L |
| May | 21 | 6/3/2024 | + | HUC | Cole Ragans* | 3R | At | COL | Ranger Suarez* | 3R |
| May | OFF | 6/4/2024 | ||||||||
| May | 22 | 6/5/2024 | CRC | Sonny Gray | 4R | At | COL | Tarik Skubal* | 2L | |
| May | 23 | 6/6/2024 | CRC | Michael Wacha | E | At | COL | Zac Gallen | 2L | |
| May | 24 | 6/7/2024 | CRC | Garrett Crochet* | 2L | At | COL | Erick Fedde | 1R | |
| + Indicates In Division Game | ||||||||||