| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2022 | TAM | Braxton Garrett* | 8L | At | AAR | Clarke Schmidt | 7R | |
| September | 2 | 9/10/2022 | TAM | Luis Severino | 2R | At | AAR | Cristian Javier | E | |
| September | 3 | 9/11/2022 | TAM | Kyle Bradish | 4L | At | AAR | J.T. Brubaker | 2R | |
| September | 4 | 9/12/2022 | CUB | Glenn Otto | 6L | At | TAM | Trevor Rogers* | 8L | |
| September | 5 | 9/13/2022 | CUB | Zach Plesac | 5R | At | TAM | Zack Greinke | 1L | |
| September | 6 | 9/14/2022 | CUB | Hunter Greene | 3L | At | TAM | Jose Urquidy | 3L | |
| September | OFF | 9/15/2022 | ||||||||
| September | 7 | 9/16/2022 | DUB | Michael Wacha | 5L | At | TAM | Kyle Bradish | 4L | |
| September | 8 | 9/17/2022 | DUB | Jose Quintana* | 1L | At | TAM | Trevor Rogers* | 8L | |
| September | 9 | 9/18/2022 | DUB | Johnny Cueto | 1R | At | TAM | Zack Greinke | 1L | |
| September | 10 | 9/19/2022 | HMA | Dean Kremer | 1R | At | TAM | Johan Oviedo | 3L | |
| September | 11 | 9/20/2022 | HMA | Trevor Williams | 8R | At | TAM | Braxton Garrett* | 8L | |
| September | 12 | 9/21/2022 | HMA | Marco Gonzales* | 1R | At | TAM | Kyle Bradish | 4L | |
| September | 13 | 9/22/2022 | TAM | Trevor Rogers* | 8L | At | HUC | Drew Rasmussen | 4L | |
| September | 14 | 9/23/2022 | TAM | Luis Severino | 2R | At | HUC | Cal Quantrill | 2L | |
| September | 15 | 9/24/2022 | TAM | Jose Urquidy | 3L | At | HUC | Chris Bassitt | 3R | |
| September | OFF | 9/25/2022 | ||||||||
| September | 16 | 9/26/2022 | + | TAM | Corey Kluber | 1R | At | DYE | Marcus Stroman | 3R |
| September | 17 | 9/27/2022 | + | TAM | Trevor Rogers* | 8L | At | DYE | Ross Stripling | 3L |
| September | 18 | 9/28/2022 | + | TAM | Zack Greinke | 1L | At | DYE | Alek Manoah | 5R |
| September | 19 | 9/29/2022 | + | TAM | Jose Urquidy | 3L | At | DYE | Aaron Nola | 3L |
| September | 20 | 9/30/2022 | + | TAM | Kyle Bradish | 4L | At | DYE | Miles Mikolas | 2L |
| September | 21 | 10/1/2022 | + | GGG | James Kaprielian | 2L | At | TAM | Luis Severino | 2R |
| September | 22 | 10/2/2022 | + | GGG | Framber Valdez* | 2L | At | TAM | Trevor Rogers* | 8L |
| September | 23 | 10/3/2022 | + | GGG | Patrick Sandoval* | 8L | At | TAM | Johan Oviedo | 3L |
| September | 24 | 10/4/2022 | + | GGG | Dustin May | 2L | At | TAM | Jose Urquidy | 3L |
| + Indicates In Division Game | ||||||||||