| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2022 | HUC | Blake Snell* | 2R | At | DAL | Nick Lodolo* | 8L | |
| September | 2 | 9/10/2022 | HUC | Chris Bassitt | 3R | At | DAL | Eduardo Rodriguez* | 6R | |
| September | 3 | 9/11/2022 | HUC | Joe Ryan | 2L | At | DAL | Drey Jameson | 7L | |
| September | 4 | 9/12/2022 | OAK | Jameson Taillon | E | At | HUC | Drew Rasmussen | 4L | |
| September | 5 | 9/13/2022 | OAK | Dylan Cease | 3R | At | HUC | Cal Quantrill | 2L | |
| September | 6 | 9/14/2022 | OAK | Merrill Kelly | 3R | At | HUC | Reid Detmers* | 2L | |
| September | OFF | 9/15/2022 | ||||||||
| September | 7 | 9/16/2022 | HUC | Joe Ryan | 2L | At | HMA | Marco Gonzales* | 1R | |
| September | 8 | 9/17/2022 | HUC | Drew Rasmussen | 4L | At | HMA | Hunter Brown | 4L | |
| September | 9 | 9/18/2022 | HUC | Cal Quantrill | 2L | At | HMA | Domingo German | 1L | |
| September | 10 | 9/19/2022 | HUC | Chris Bassitt | 3R | At | DUB | Nestor Cortes* | 4L | |
| September | 11 | 9/20/2022 | HUC | Blake Snell* | 2R | At | DUB | Justin Verlander | 3L | |
| September | 12 | 9/21/2022 | HUC | Bryse Wilson | 3R | At | DUB | Michael Wacha | 5L | |
| September | 13 | 9/22/2022 | TAM | Trevor Rogers* | 8L | At | HUC | Drew Rasmussen | 4L | |
| September | 14 | 9/23/2022 | TAM | Luis Severino | 2R | At | HUC | Cal Quantrill | 2L | |
| September | 15 | 9/24/2022 | TAM | Jose Urquidy | 3L | At | HUC | Chris Bassitt | 3R | |
| September | OFF | 9/25/2022 | ||||||||
| September | 16 | 9/26/2022 | + | HUC | Blake Snell* | 2R | At | VRN | Logan Gilbert | 6L |
| September | 17 | 9/27/2022 | + | HUC | Joe Ryan | 2L | At | VRN | Gerrit Cole | E |
| September | 18 | 9/28/2022 | + | HUC | Cal Quantrill | 2L | At | VRN | Alex Wood* | 8L |
| September | 19 | 9/29/2022 | + | HUC | Chris Bassitt | 3R | At | VRN | Max Scherzer | 1R |
| September | 20 | 9/30/2022 | + | HUC | Reid Detmers* | 2L | At | VRN | Garrett Hill | 4L |
| September | 21 | 10/1/2022 | + | WRK | Julio Urias* | 1R | At | HUC | Blake Snell* | 2R |
| September | 22 | 10/2/2022 | + | WRK | Tony Gonsolin | 2L | At | HUC | Drew Rasmussen | 4L |
| September | 23 | 10/3/2022 | + | WRK | Spencer Strider | E | At | HUC | Cal Quantrill | 2L |
| September | 24 | 10/4/2022 | + | WRK | Paul Blackburn | 1R | At | HUC | Chris Bassitt | 3R |
| + Indicates In Division Game | ||||||||||