| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2022 | CHI | German Marquez | 3R | At | HOH | Mike Clevinger | 1L | |
| September | 2 | 9/10/2022 | CHI | Beau Brieske | 6L | At | HOH | Logan Webb | 5R | |
| September | 3 | 9/11/2022 | CHI | Adam Wainwright | E | At | HOH | Lance Lynn | 1R | |
| September | 4 | 9/12/2022 | HOH | Tyler Anderson* | E | At | JAM | Robbie Ray* | 2L | |
| September | 5 | 9/13/2022 | HOH | Ranger Suarez* | 5L | At | JAM | Jordan Montgomery* | 4L | |
| September | 6 | 9/14/2022 | HOH | Mike Clevinger | 1L | At | JAM | Max Fried* | 1L | |
| September | OFF | 9/15/2022 | ||||||||
| September | 7 | 9/16/2022 | + | HOH | Logan Webb | 5R | At | AAR | Cristian Javier | E |
| September | 8 | 9/17/2022 | + | HOH | Tyler Anderson* | E | At | AAR | Noah Syndergaard | 2R |
| September | 9 | 9/18/2022 | + | HOH | Lance Lynn | 1R | At | AAR | Shohei Ohtani | 3R |
| September | 10 | 9/19/2022 | + | HOH | Ranger Suarez* | 5L | At | AAR | J.T. Brubaker | 2R |
| September | 11 | 9/20/2022 | + | HOH | Mike Clevinger | 1L | At | AAR | Michael Kopech | 2R |
| September | 12 | 9/21/2022 | + | NYY | Corbin Burnes | E | At | HOH | Logan Webb | 5R |
| September | 13 | 9/22/2022 | + | NYY | Luis Castillo | E | At | HOH | Tyler Anderson* | E |
| September | 14 | 9/23/2022 | + | NYY | Alex Cobb | 1R | At | HOH | Lance Lynn | 1R |
| September | 15 | 9/24/2022 | + | NYY | Lucas Giolito | 9L | At | HOH | Jalen Beeks* | 3R |
| September | OFF | 9/25/2022 | ||||||||
| September | 16 | 9/26/2022 | + | HMA | Marco Gonzales* | 1R | At | HOH | Logan Webb | 5R |
| September | 17 | 9/27/2022 | + | HMA | Sandy Alcantara | 2L | At | HOH | Tyler Anderson* | E |
| September | 18 | 9/28/2022 | + | HMA | Frankie Montas | 2R | At | HOH | Lance Lynn | 1R |
| September | 19 | 9/29/2022 | + | HMA | Jesus Luzardo* | 3L | At | HOH | Connor Overton | 2L |
| September | 20 | 9/30/2022 | + | HMA | Hunter Brown | 4L | At | HOH | Mike Clevinger | 1L |
| September | 21 | 10/1/2022 | + | HOH | Logan Webb | 5R | At | NYY | Corbin Burnes | E |
| September | 22 | 10/2/2022 | + | HOH | Tyler Anderson* | E | At | NYY | Luis Castillo | E |
| September | 23 | 10/3/2022 | + | HOH | Lance Lynn | 1R | At | NYY | Nick Pivetta | 2R |
| September | 24 | 10/4/2022 | + | HOH | Ranger Suarez* | 5L | At | NYY | Lucas Giolito | 9L |
| + Indicates In Division Game | ||||||||||