| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2022 | COL | Brandon Woodruff | 5L | At | CUB | Hunter Greene | 3L | |
| September | 2 | 9/10/2022 | COL | Tyler Mahle | 5L | At | CUB | Pablo Lopez | 3R | |
| September | 3 | 9/11/2022 | COL | Edward Cabrera | 3L | At | CUB | Dane Dunning | E | |
| September | 4 | 9/12/2022 | AAR | Eric Lauer* | 1L | At | COL | Tarik Skubal* | 1R | |
| September | 5 | 9/13/2022 | AAR | Michael Kopech | 2R | At | COL | Clayton Kershaw* | E | |
| September | 6 | 9/14/2022 | AAR | Clarke Schmidt | 7R | At | COL | Brandon Woodruff | 5L | |
| September | OFF | 9/15/2022 | ||||||||
| September | 7 | 9/16/2022 | + | COL | Tyler Mahle | 5L | At | JAM | Kyle Gibson | E |
| September | 8 | 9/17/2022 | + | COL | Zac Gallen | 3L | At | JAM | Kyle Freeland* | 6R |
| September | 9 | 9/18/2022 | + | COL | Clayton Kershaw* | E | At | JAM | Robbie Ray* | 2L |
| September | 10 | 9/19/2022 | + | COL | Brandon Woodruff | 5L | At | JAM | Jordan Montgomery* | 4L |
| September | 11 | 9/20/2022 | + | COL | Justin Steele* | E | At | JAM | Rich Hill* | 2L |
| September | 12 | 9/21/2022 | + | WRK | Julio Urias* | 1R | At | COL | Tyler Mahle | 5L |
| September | 13 | 9/22/2022 | + | WRK | Tony Gonsolin | 2L | At | COL | Zac Gallen | 3L |
| September | 14 | 9/23/2022 | + | WRK | Spencer Strider | E | At | COL | Clayton Kershaw* | E |
| September | 15 | 9/24/2022 | + | WRK | Paul Blackburn | 1R | At | COL | Brandon Woodruff | 5L |
| September | OFF | 9/25/2022 | ||||||||
| September | 16 | 9/26/2022 | OAK | Merrill Kelly | 3R | At | COL | Tyler Mahle | 5L | |
| September | 17 | 9/27/2022 | OAK | Martin Perez* | 2L | At | COL | Zac Gallen | 3L | |
| September | 18 | 9/28/2022 | OAK | Jose Suarez* | 3L | At | COL | Clayton Kershaw* | E | |
| September | 19 | 9/29/2022 | DAL | Carlos Carrasco | 2L | At | COL | Brandon Woodruff | 5L | |
| September | 20 | 9/30/2022 | DAL | Jose Berrios | 3R | At | COL | Sean Manaea* | 6L | |
| September | 21 | 10/1/2022 | DAL | Nick Lodolo* | 8L | At | COL | Tyler Mahle | 5L | |
| September | 22 | 10/2/2022 | COL | Justin Steele* | E | At | SRD | Austin Voth | 1R | |
| September | 23 | 10/3/2022 | COL | Clayton Kershaw* | E | At | SRD | Chris Flexen | 6L | |
| September | 24 | 10/4/2022 | COL | Brandon Woodruff | 5L | At | SRD | Ian Anderson | 8L | |
| + Indicates In Division Game | ||||||||||