| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2022 | CHI | German Marquez | 3R | At | HOH | Mike Clevinger | 1L | |
| September | 2 | 9/10/2022 | CHI | Beau Brieske | 6L | At | HOH | Logan Webb | 5R | |
| September | 3 | 9/11/2022 | CHI | Adam Wainwright | E | At | HOH | Lance Lynn | 1R | |
| September | 4 | 9/12/2022 | BUR | Matt Manning | 2R | At | CHI | Aaron Civale | E | |
| September | 5 | 9/13/2022 | BUR | Chris Archer | 2L | At | CHI | J.P. Feyereisen | E | |
| September | 6 | 9/14/2022 | BUR | Daniel Lynch* | 1L | At | CHI | German Marquez | 3R | |
| September | OFF | 9/15/2022 | ||||||||
| September | 7 | 9/16/2022 | + | SRD | Yu Darvish | 3L | At | CHI | Adam Wainwright | E |
| September | 8 | 9/17/2022 | + | SRD | Patrick Corbin* | E | At | CHI | Aaron Civale | E |
| September | 9 | 9/18/2022 | + | SRD | Keegan Thompson | 2L | At | CHI | J.P. Feyereisen | E |
| September | 10 | 9/19/2022 | + | SRD | Ian Anderson | 8L | At | CHI | German Marquez | 3R |
| September | 11 | 9/20/2022 | + | SRD | Hayden Wesneski | 5L | At | CHI | Jordan Lyles | 4R |
| September | 12 | 9/21/2022 | + | CHI | Adam Wainwright | E | At | DYE | Miles Mikolas | 2L |
| September | 13 | 9/22/2022 | + | CHI | Beau Brieske | 6L | At | DYE | Ross Stripling | 3L |
| September | 14 | 9/23/2022 | + | CHI | J.P. Feyereisen | E | At | DYE | Aaron Nola | 3L |
| September | 15 | 9/24/2022 | + | CHI | German Marquez | 3R | At | DYE | Alek Manoah | 5R |
| September | OFF | 9/25/2022 | ||||||||
| September | 16 | 9/26/2022 | + | CHI | Adam Wainwright | E | At | GGG | James Kaprielian | 2L |
| September | 17 | 9/27/2022 | + | CHI | Aaron Civale | E | At | GGG | Framber Valdez* | 2L |
| September | 18 | 9/28/2022 | + | CHI | Beau Brieske | 6L | At | GGG | Patrick Sandoval* | 8L |
| September | 19 | 9/29/2022 | + | CHI | German Marquez | 3R | At | GGG | Dustin May | 2L |
| September | 20 | 9/30/2022 | + | CHI | Jordan Lyles | 4R | At | GGG | Michael Lorenzen | 4R |
| September | 21 | 10/1/2022 | + | DYE | Marcus Stroman | 3R | At | CHI | Adam Wainwright | E |
| September | 22 | 10/2/2022 | + | DYE | Alek Manoah | 5R | At | CHI | J.P. Feyereisen | E |
| September | 23 | 10/3/2022 | + | DYE | Aaron Nola | 3L | At | CHI | Aaron Civale | E |
| September | 24 | 10/4/2022 | + | DYE | Joey Wentz* | 1L | At | CHI | German Marquez | 3R |
| + Indicates In Division Game | ||||||||||