| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2022 | TAM | Braxton Garrett* | 8L | At | AAR | Clarke Schmidt | 7R | |
| September | 2 | 9/10/2022 | TAM | Luis Severino | 2R | At | AAR | Cristian Javier | E | |
| September | 3 | 9/11/2022 | TAM | Kyle Bradish | 4L | At | AAR | J.T. Brubaker | 2R | |
| September | 4 | 9/12/2022 | AAR | Eric Lauer* | 1L | At | COL | Tarik Skubal* | 1R | |
| September | 5 | 9/13/2022 | AAR | Michael Kopech | 2R | At | COL | Clayton Kershaw* | E | |
| September | 6 | 9/14/2022 | AAR | Clarke Schmidt | 7R | At | COL | Brandon Woodruff | 5L | |
| September | OFF | 9/15/2022 | ||||||||
| September | 7 | 9/16/2022 | + | HOH | Logan Webb | 5R | At | AAR | Cristian Javier | E |
| September | 8 | 9/17/2022 | + | HOH | Tyler Anderson* | E | At | AAR | Noah Syndergaard | 2R |
| September | 9 | 9/18/2022 | + | HOH | Lance Lynn | 1R | At | AAR | Shohei Ohtani | 3R |
| September | 10 | 9/19/2022 | + | HOH | Ranger Suarez* | 5L | At | AAR | J.T. Brubaker | 2R |
| September | 11 | 9/20/2022 | + | HOH | Mike Clevinger | 1L | At | AAR | Michael Kopech | 2R |
| September | 12 | 9/21/2022 | + | AAR | Cristian Javier | E | At | OAK | Martin Perez* | 2L |
| September | 13 | 9/22/2022 | + | AAR | Noah Syndergaard | 2R | At | OAK | Jose Suarez* | 3L |
| September | 14 | 9/23/2022 | + | AAR | Shohei Ohtani | 3R | At | OAK | Jameson Taillon | E |
| September | 15 | 9/24/2022 | + | AAR | J.T. Brubaker | 2R | At | OAK | Luis Garcia | 3R |
| September | OFF | 9/25/2022 | ||||||||
| September | 16 | 9/26/2022 | + | NYY | Corbin Burnes | E | At | AAR | Michael Kopech | 2R |
| September | 17 | 9/27/2022 | + | NYY | Luis Castillo | E | At | AAR | Cristian Javier | E |
| September | 18 | 9/28/2022 | + | NYY | Tanner Houck | 5R | At | AAR | Noah Syndergaard | 2R |
| September | 19 | 9/29/2022 | + | NYY | Lucas Giolito | 9L | At | AAR | Shohei Ohtani | 3R |
| September | 20 | 9/30/2022 | + | NYY | Nick Martinez | E | At | AAR | J.T. Brubaker | 2R |
| September | 21 | 10/1/2022 | + | AAR | Michael Kopech | 2R | At | HMA | Marco Gonzales* | 1R |
| September | 22 | 10/2/2022 | + | AAR | Cristian Javier | E | At | HMA | Dean Kremer | 1R |
| September | 23 | 10/3/2022 | + | AAR | Noah Syndergaard | 2R | At | HMA | Sandy Alcantara | 2L |
| September | 24 | 10/4/2022 | + | AAR | Shohei Ohtani | 3R | At | HMA | Frankie Montas | 2R |
| + Indicates In Division Game | ||||||||||