| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| August | 1 | 8/14/2022 | HOH | Ranger Suarez* | 5L | At | HUC | Cal Quantrill | 2L | |
| August | 2 | 8/15/2022 | HOH | Logan Webb | 5R | At | HUC | Chris Bassitt | 3R | |
| August | 3 | 8/16/2022 | HOH | Lance Lynn | 1R | At | HUC | Joe Ryan | 2L | |
| August | 4 | 8/17/2022 | CRC | Kevin Gausman | 4L | At | HOH | Jalen Beeks* | 3R | |
| August | 5 | 8/18/2022 | CRC | Kyle Wright | 2R | At | HOH | Tyler Anderson* | E | |
| August | 6 | 8/19/2022 | CRC | Sonny Gray | 4L | At | HOH | Ranger Suarez* | 5L | |
| August | OFF | 8/20/2022 | ||||||||
| August | 7 | 8/21/2022 | + | AAR | J.T. Brubaker | 2R | At | HOH | Logan Webb | 5R |
| August | 8 | 8/22/2022 | + | AAR | Eric Lauer* | 1L | At | HOH | Lance Lynn | 1R |
| August | 9 | 8/23/2022 | + | AAR | Tylor Megill | 8R | At | HOH | Tyler Anderson* | E |
| August | 10 | 8/24/2022 | + | AAR | Shohei Ohtani | 3R | At | HOH | Ranger Suarez* | 5L |
| August | 11 | 8/25/2022 | + | AAR | Noah Syndergaard | 2R | At | HOH | Jalen Beeks* | 3R |
| August | 12 | 8/26/2022 | + | HOH | Logan Webb | 5R | At | OAK | Jameson Taillon | E |
| August | 13 | 8/27/2022 | + | HOH | Lance Lynn | 1R | At | OAK | Dylan Cease | 3R |
| August | 14 | 8/28/2022 | + | HOH | Connor Overton | 2L | At | OAK | Merrill Kelly | 3R |
| August | 15 | 8/29/2022 | + | HOH | Tyler Anderson* | E | At | OAK | Martin Perez* | 2L |
| August | OFF | 8/30/2022 | ||||||||
| August | 16 | 8/31/2022 | + | HOH | Logan Webb | 5R | At | HMA | Sandy Alcantara | 2L |
| August | 17 | 9/1/2022 | + | HOH | Lance Lynn | 1R | At | HMA | Marco Gonzales* | 1R |
| August | 18 | 9/2/2022 | + | HOH | Ranger Suarez* | 5L | At | HMA | Domingo German | 1L |
| August | 19 | 9/3/2022 | + | HOH | Connor Overton | 2L | At | HMA | Brady Singer | 1R |
| August | 20 | 9/4/2022 | + | HOH | Jalen Beeks* | 3R | At | HMA | Sandy Alcantara | 2L |
| August | 21 | 9/5/2022 | + | OAK | Luis Garcia | 3R | At | HOH | Logan Webb | 5R |
| August | 22 | 9/6/2022 | + | OAK | Jeffrey Springs* | 6R | At | HOH | Lance Lynn | 1R |
| August | 23 | 9/7/2022 | + | OAK | Jameson Taillon | E | At | HOH | Tyler Anderson* | E |
| August | 24 | 9/8/2022 | + | OAK | Dylan Cease | 3R | At | HOH | Connor Overton | 2L |
| + Indicates In Division Game | ||||||||||