| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| August | 1 | 8/14/2022 | NYY | Nick Pivetta | 2R | At | COL | Tyler Mahle | 5L | |
| August | 2 | 8/15/2022 | NYY | Nick Martinez | E | At | COL | Zac Gallen | 3L | |
| August | 3 | 8/16/2022 | NYY | Luis Castillo | E | At | COL | Tarik Skubal* | 1R | |
| August | 4 | 8/17/2022 | COL | Clayton Kershaw* | E | At | TAM | Braxton Garrett* | 8L | |
| August | 5 | 8/18/2022 | COL | Brandon Woodruff | 5L | At | TAM | Corey Kluber | 1R | |
| August | 6 | 8/19/2022 | COL | Tyler Mahle | 5L | At | TAM | Zack Greinke | 1L | |
| August | OFF | 8/20/2022 | ||||||||
| August | 7 | 8/21/2022 | + | COL | Zac Gallen | 3L | At | HUC | Chris Bassitt | 3R |
| August | 8 | 8/22/2022 | + | COL | Tarik Skubal* | 1R | At | HUC | Joe Ryan | 2L |
| August | 9 | 8/23/2022 | + | COL | Clayton Kershaw* | E | At | HUC | Reid Detmers* | 2L |
| August | 10 | 8/24/2022 | + | COL | Brandon Woodruff | 5L | At | HUC | Cal Quantrill | 2L |
| August | 11 | 8/25/2022 | + | COL | Tyler Mahle | 5L | At | HUC | Drew Rasmussen | 4L |
| August | 12 | 8/26/2022 | + | VRN | Logan Gilbert | 6L | At | COL | Zac Gallen | 3L |
| August | 13 | 8/27/2022 | + | VRN | Gerrit Cole | E | At | COL | Tarik Skubal* | 1R |
| August | 14 | 8/28/2022 | + | VRN | Alex Wood* | 8L | At | COL | Clayton Kershaw* | E |
| August | 15 | 8/29/2022 | + | VRN | Max Scherzer | 1R | At | COL | Brandon Woodruff | 5L |
| August | OFF | 8/30/2022 | ||||||||
| August | 16 | 8/31/2022 | + | JAM | Kyle Gibson | E | At | COL | Tyler Mahle | 5L |
| August | 17 | 9/1/2022 | + | JAM | Kyle Freeland* | 6R | At | COL | Zac Gallen | 3L |
| August | 18 | 9/2/2022 | + | JAM | Robbie Ray* | 2L | At | COL | Tarik Skubal* | 1R |
| August | 19 | 9/3/2022 | + | JAM | Jordan Montgomery* | 4L | At | COL | Clayton Kershaw* | E |
| August | 20 | 9/4/2022 | + | JAM | Max Fried* | 1L | At | COL | Brandon Woodruff | 5L |
| August | 21 | 9/5/2022 | + | COL | Tyler Mahle | 5L | At | VRN | David Peterson* | 4L |
| August | 22 | 9/6/2022 | + | COL | Zac Gallen | 3L | At | VRN | Logan Gilbert | 6L |
| August | 23 | 9/7/2022 | + | COL | Tarik Skubal* | 1R | At | VRN | Gerrit Cole | E |
| August | 24 | 9/8/2022 | + | COL | Clayton Kershaw* | E | At | VRN | Alex Wood* | 8L |
| + Indicates In Division Game | ||||||||||