| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| August | 1 | 8/14/2022 | CHI | J.P. Feyereisen | E | At | DAL | Nick Lodolo* | 8L | |
| August | 2 | 8/15/2022 | CHI | Aaron Civale | E | At | DAL | Shane McClanahan* | 2R | |
| August | 3 | 8/16/2022 | CHI | Beau Brieske | 6L | At | DAL | Jose Berrios | 3R | |
| August | 4 | 8/17/2022 | VRN | Alex Wood* | 8L | At | CHI | Adam Wainwright | E | |
| August | 5 | 8/18/2022 | VRN | Max Scherzer | 1R | At | CHI | German Marquez | 3R | |
| August | 6 | 8/19/2022 | VRN | David Peterson* | 4L | At | CHI | Bryan Baker | 1R | |
| August | OFF | 8/20/2022 | ||||||||
| August | 7 | 8/21/2022 | CHI | Aaron Civale | E | At | CRC | Jacob Degrom | 1L | |
| August | 8 | 8/22/2022 | CHI | Adam Wainwright | E | At | CRC | Triston McKenzie | 1L | |
| August | 9 | 8/23/2022 | CHI | German Marquez | 3R | At | CRC | Carlos Rodon* | 1L | |
| August | 10 | 8/24/2022 | CHI | Bryan Baker | 1R | At | NYY | Nick Pivetta | 2R | |
| August | 11 | 8/25/2022 | CHI | Beau Brieske | 6L | At | NYY | Nick Martinez | E | |
| August | 12 | 8/26/2022 | CHI | Aaron Civale | E | At | NYY | Luis Castillo | E | |
| August | 13 | 8/27/2022 | JAM | Robbie Ray* | 2L | At | CHI | Adam Wainwright | E | |
| August | 14 | 8/28/2022 | JAM | Jordan Montgomery* | 4L | At | CHI | German Marquez | 3R | |
| August | 15 | 8/29/2022 | JAM | Max Fried* | 1L | At | CHI | Bryan Baker | 1R | |
| August | OFF | 8/30/2022 | ||||||||
| August | 16 | 8/31/2022 | + | CHI | Beau Brieske | 6L | At | SRD | Yu Darvish | 3L |
| August | 17 | 9/1/2022 | + | CHI | Adam Wainwright | E | At | SRD | Patrick Corbin* | E |
| August | 18 | 9/2/2022 | + | CHI | Aaron Civale | E | At | SRD | Madison Bumgarner* | 2L |
| August | 19 | 9/3/2022 | + | CHI | Bryan Baker | 1R | At | SRD | Ian Anderson | 8L |
| August | 20 | 9/4/2022 | + | CHI | German Marquez | 3R | At | SRD | Mitch Keller | 1R |
| August | 21 | 9/5/2022 | + | TAM | Luis Severino | 2R | At | CHI | Beau Brieske | 6L |
| August | 22 | 9/6/2022 | + | TAM | Kyle Bradish | 4L | At | CHI | Adam Wainwright | E |
| August | 23 | 9/7/2022 | + | TAM | Trevor Rogers* | 8L | At | CHI | Aaron Civale | E |
| August | 24 | 9/8/2022 | + | TAM | Corey Kluber | 1R | At | CHI | Bryan Baker | 1R |
| + Indicates In Division Game | ||||||||||