| 2022 Schedule For CHI | |||
| Month | Game | Strat Date | Matchup |
| March | 1 | 4/7/2021 | CHI at HUC |
| March | 2 | 4/8/2021 | CHI at HUC |
| March | 3 | 4/9/2021 | CHI at HUC |
| March | OFF | 4/10/2021 | |
| March | 4 | 4/11/2021 | HMA at CHI |
| March | 5 | 4/12/2021 | HMA at CHI |
| March | 6 | 4/13/2021 | HMA at CHI |
| March | 7 | 4/14/2021 | CUB at CHI |
| March | 8 | 4/15/2021 | CUB at CHI |
| March | 9 | 4/16/2021 | CUB at CHI |
| March | 10 | 4/17/2021 | JAM at CHI |
| March | 11 | 4/18/2021 | JAM at CHI |
| March | 12 | 4/19/2021 | JAM at CHI |
| March | OFF | 4/20/2021 | |
| March | 13 | 4/21/2021 | CHI at AAR |
| March | 14 | 4/22/2021 | CHI at AAR |
| March | 15 | 4/23/2021 | CHI at AAR |
| March | 16 | 4/24/2021 | CHI at BUR |
| March | 17 | 4/25/2021 | CHI at BUR |
| March | 18 | 4/26/2021 | CHI at BUR |
| March | 19 | 4/27/2021 | CHI at VRN |
| March | 20 | 4/28/2021 | CHI at VRN |
| March | 21 | 4/29/2021 | CHI at VRN |
| April | 1 | 4/30/2021 | OAK at CHI |
| April | 2 | 5/1/2021 | OAK at CHI |
| April | 3 | 5/2/2021 | OAK at CHI |
| April | OFF | 5/3/2021 | |
| April | 4 | 5/4/2021 | CWC at CHI |
| April | 5 | 5/5/2021 | CWC at CHI |
| April | 6 | 5/6/2021 | CWC at CHI |
| April | 7 | 5/7/2021 | CHI at WRK |
| April | 8 | 5/8/2021 | CHI at WRK |
| April | 9 | 5/9/2021 | CHI at WRK |
| April | 10 | 5/10/2021 | CHI at HOH |
| April | 11 | 5/11/2021 | CHI at HOH |
| April | 12 | 5/12/2021 | CHI at HOH |
| April | OFF | 5/13/2021 | |
| April | 13 | 5/14/2021 | CRC at CHI |
| April | 14 | 5/15/2021 | CRC at CHI |
| April | 15 | 5/16/2021 | CRC at CHI |
| April | 16 | 5/17/2021 | HUC at CHI |
| April | 17 | 5/18/2021 | HUC at CHI |
| April | 18 | 5/19/2021 | HUC at CHI |
| April | 19 | 5/20/2021 | CHI at HMA |
| April | 20 | 5/21/2021 | CHI at HMA |
| April | 21 | 5/22/2021 | CHI at HMA |
| May | 1 | 5/23/2021 | CHI at CUB |
| May | 2 | 5/24/2021 | CHI at CUB |
| May | 3 | 5/25/2021 | CHI at CUB |
| May | OFF | 5/26/2021 | |
| May | 4 | 5/27/2021 | DUB at CHI |
| May | 5 | 5/28/2021 | DUB at CHI |
| May | 6 | 5/29/2021 | DUB at CHI |
| May | 7 | 5/30/2021 | NYY at CHI |
| May | 8 | 5/31/2021 | NYY at CHI |
| May | 9 | 6/1/2021 | NYY at CHI |
| May | 10 | 6/2/2021 | CHI at COL |
| May | 11 | 6/3/2021 | CHI at COL |
| May | 12 | 6/4/2021 | CHI at COL |
| May | OFF | 6/5/2021 | |
| May | 13 | 6/6/2021 | * SRD at CHI |
| May | 14 | 6/7/2021 | * SRD at CHI |
| May | 15 | 6/8/2021 | * SRD at CHI |
| May | 16 | 6/9/2021 | * SRD at CHI |
| May | 17 | 6/10/2021 | * SRD at CHI |
| May | 18 | 6/11/2021 | * CHI at TAM |
| May | 19 | 6/12/2021 | * CHI at TAM |
| May | 20 | 6/13/2021 | * CHI at TAM |
| May | 21 | 6/14/2021 | * CHI at TAM |
| May | OFF | 6/15/2021 | |
| May | 22 | 6/16/2021 | CHI at JAM |
| May | 23 | 6/17/2021 | CHI at JAM |
| May | 24 | 6/18/2021 | CHI at JAM |
| June | 1 | 6/19/2021 | AAR at CHI |
| June | 2 | 6/20/2021 | AAR at CHI |
| June | 3 | 6/21/2021 | AAR at CHI |
| June | 4 | 6/22/2021 | BUR at CHI |
| June | 5 | 6/23/2021 | BUR at CHI |
| June | 6 | 6/24/2021 | BUR at CHI |
| June | OFF | 6/25/2021 | |
| June | 7 | 6/26/2021 | * CHI at SRD |
| June | 8 | 6/27/2021 | * CHI at SRD |
| June | 9 | 6/28/2021 | * CHI at SRD |
| June | 10 | 6/29/2021 | * CHI at SRD |
| June | 11 | 6/30/2021 | * CHI at SRD |
| June | 12 | 7/1/2021 | * DYE at CHI |
| June | 13 | 7/2/2021 | * DYE at CHI |
| June | 14 | 7/3/2021 | * DYE at CHI |
| June | 15 | 7/4/2021 | * DYE at CHI |
| June | OFF | 7/5/2021 | |
| June | 16 | 7/6/2021 | * CHI at GGG |
| June | 17 | 7/7/2021 | * CHI at GGG |
| June | 18 | 7/8/2021 | * CHI at GGG |
| June | 19 | 7/9/2021 | * CHI at GGG |
| June | 20 | 7/10/2021 | * CHI at GGG |
| June | 21 | 7/11/2021 | * TAM at CHI |
| June | 22 | 7/12/2021 | * TAM at CHI |
| June | 23 | 7/13/2021 | * TAM at CHI |
| June | 24 | 7/14/2021 | * TAM at CHI |
| All Star Break | OFF | 7/15/2021 | |
| All Star Break | OFF | 7/16/2021 | |
| All Star Break | OFF | 7/17/2021 | |
| July | 1 | 7/18/2021 | VRN at CHI |
| July | 2 | 7/19/2021 | VRN at CHI |
| July | 3 | 7/20/2021 | VRN at CHI |
| July | 4 | 7/21/2021 | CHI at OAK |
| July | 5 | 7/22/2021 | CHI at OAK |
| July | 6 | 7/23/2021 | CHI at OAK |
| July | OFF | 7/24/2021 | |
| July | 7 | 7/25/2021 | CHI at DUB |
| July | 8 | 7/26/2021 | CHI at DUB |
| July | 9 | 7/27/2021 | CHI at DUB |
| July | 10 | 7/28/2021 | CHI at NYY |
| July | 11 | 7/29/2021 | CHI at NYY |
| July | 12 | 7/30/2021 | CHI at NYY |
| July | 13 | 7/31/2021 | COL at CHI |
| July | 14 | 8/1/2021 | COL at CHI |
| July | 15 | 8/2/2021 | COL at CHI |
| July | OFF | 8/3/2021 | |
| July | 16 | 8/4/2021 | * GGG at CHI |
| July | 17 | 8/5/2021 | * GGG at CHI |
| July | 18 | 8/6/2021 | * GGG at CHI |
| July | 19 | 8/7/2021 | * GGG at CHI |
| July | 20 | 8/8/2021 | * GGG at CHI |
| July | 21 | 8/9/2021 | * CHI at DYE |
| July | 22 | 8/10/2021 | * CHI at DYE |
| July | 23 | 8/11/2021 | * CHI at DYE |
| July | 24 | 8/12/2021 | * CHI at DYE |
| Trade Deadline | OFF | 8/13/2021 | |
| August | 1 | 8/14/2021 | CHI at CWC |
| August | 2 | 8/15/2021 | CHI at CWC |
| August | 3 | 8/16/2021 | CHI at CWC |
| August | 4 | 8/17/2021 | WRK at CHI |
| August | 5 | 8/18/2021 | WRK at CHI |
| August | 6 | 8/19/2021 | WRK at CHI |
| August | OFF | 8/20/2021 | |
| August | 7 | 8/21/2021 | * TAM at CHI |
| August | 8 | 8/22/2021 | * TAM at CHI |
| August | 9 | 8/23/2021 | * TAM at CHI |
| August | 10 | 8/24/2021 | * TAM at CHI |
| August | 11 | 8/25/2021 | * TAM at CHI |
| August | 12 | 8/26/2021 | * CHI at SRD |
| August | 13 | 8/27/2021 | * CHI at SRD |
| August | 14 | 8/28/2021 | * CHI at SRD |
| August | 15 | 8/29/2021 | * CHI at SRD |
| August | OFF | 8/30/2021 | |
| August | 16 | 8/31/2021 | * CHI at DYE |
| August | 17 | 9/1/2021 | * CHI at DYE |
| August | 18 | 9/2/2021 | * CHI at DYE |
| August | 19 | 9/3/2021 | * CHI at DYE |
| August | 20 | 9/4/2021 | * CHI at DYE |
| August | 21 | 9/5/2021 | * SRD at CHI |
| August | 22 | 9/6/2021 | * SRD at CHI |
| August | 23 | 9/7/2021 | * SRD at CHI |
| August | 24 | 9/8/2021 | * SRD at CHI |
| September | 1 | 9/9/2021 | HOH at CHI |
| September | 2 | 9/10/2021 | HOH at CHI |
| September | 3 | 9/11/2021 | HOH at CHI |
| September | 4 | 9/12/2021 | CHI at CRC |
| September | 5 | 9/13/2021 | CHI at CRC |
| September | 6 | 9/14/2021 | CHI at CRC |
| September | OFF | 9/15/2021 | |
| September | 7 | 9/16/2021 | * CHI at TAM |
| September | 8 | 9/17/2021 | * CHI at TAM |
| September | 9 | 9/18/2021 | * CHI at TAM |
| September | 10 | 9/19/2021 | * CHI at TAM |
| September | 11 | 9/20/2021 | * CHI at TAM |
| September | 12 | 9/21/2021 | * GGG at CHI |
| September | 13 | 9/22/2021 | * GGG at CHI |
| September | 14 | 9/23/2021 | * GGG at CHI |
| September | 15 | 9/24/2021 | * GGG at CHI |
| September | OFF | 9/25/2021 | |
| September | 16 | 9/26/2021 | * DYE at CHI |
| September | 17 | 9/27/2021 | * DYE at CHI |
| September | 18 | 9/28/2021 | * DYE at CHI |
| September | 19 | 9/29/2021 | * DYE at CHI |
| September | 20 | 9/30/2021 | * DYE at CHI |
| September | 21 | 10/1/2021 | * CHI at GGG |
| September | 22 | 10/2/2021 | * CHI at GGG |
| September | 23 | 10/3/2021 | * CHI at GGG |
| September | 24 | 10/4/2021 | * CHI at GGG |