| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2021 | WRK | Matt Manning | 2L | At | DUB | Shane Bieber | 4R | |
| September | 2 | 9/10/2021 | WRK | Kenta Maeda | E | At | DUB | Rich Hill* | 5L | |
| September | 3 | 9/11/2021 | WRK | Joe Musgrove | 4R | At | DUB | Michael Wacha | 4L | |
| September | 4 | 9/12/2021 | NYY | Huascar Ynoa | E | At | WRK | Julio Urias* | 2R | |
| September | 5 | 9/13/2021 | NYY | Lucas Giolito | 2L | At | WRK | Bailey Ober | 2R | |
| September | 6 | 9/14/2021 | NYY | Tanner Houck | 1R | At | WRK | Matt Manning | 2L | |
| September | OFF | 9/15/2021 | ||||||||
| September | 7 | 9/16/2021 | + | HUC | Drew Rasmussen | E | At | WRK | Kenta Maeda | E |
| September | 8 | 9/17/2021 | + | HUC | Chris Bassitt | 1L | At | WRK | Joe Musgrove | 4R |
| September | 9 | 9/18/2021 | + | HUC | Cal Quantrill | 1L | At | WRK | Bailey Ober | 2R |
| September | 10 | 9/19/2021 | + | HUC | Blake Snell* | 5L | At | WRK | Matt Manning | 2L |
| September | 11 | 9/20/2021 | + | HUC | Jordan Holloway | 2L | At | WRK | Julio Urias* | 2R |
| September | 12 | 9/21/2021 | + | WRK | Kenta Maeda | E | At | COL | Tarik Skubal* | 3L |
| September | 13 | 9/22/2021 | + | WRK | Joe Musgrove | 4R | At | COL | Clayton Kershaw* | 6L |
| September | 14 | 9/23/2021 | + | WRK | Bailey Ober | 2R | At | COL | Vladimir Gutierrez | 2R |
| September | 15 | 9/24/2021 | + | WRK | Matt Manning | 2L | At | COL | Brandon Woodruff | 2L |
| September | OFF | 9/25/2021 | ||||||||
| September | 16 | 9/26/2021 | + | WRK | Kenta Maeda | E | At | JAM | Jordan Montgomery* | 1L |
| September | 17 | 9/27/2021 | + | WRK | Joe Musgrove | 4R | At | JAM | Max Fried* | 4R |
| September | 18 | 9/28/2021 | + | WRK | Julio Urias* | 2R | At | JAM | Robbie Ray* | 1R |
| September | 19 | 9/29/2021 | + | WRK | Matt Manning | 2L | At | JAM | Kyle Gibson | 3R |
| September | 20 | 9/30/2021 | + | WRK | Bailey Ober | 2R | At | JAM | Alex Wood* | 2R |
| September | 21 | 10/1/2021 | + | COL | Vladimir Gutierrez | 2R | At | WRK | Kenta Maeda | E |
| September | 22 | 10/2/2021 | + | COL | Mike Minor* | E | At | WRK | Joe Musgrove | 4R |
| September | 23 | 10/3/2021 | + | COL | Tyler Mahle | 8L | At | WRK | Julio Urias* | 2R |
| September | 24 | 10/4/2021 | + | COL | Clayton Kershaw* | 6L | At | WRK | Matt Manning | 2L |
| + Indicates In Division Game | ||||||||||