| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2021 | VRN | Freddy Peralta | 1L | At | CUB | Patrick Corbin* | 8L | |
| September | 2 | 9/10/2021 | VRN | Max Scherzer | 1R | At | CUB | Zach Plesac | 4L | |
| September | 3 | 9/11/2021 | VRN | Zach Eflin | 2L | At | CUB | Alek Manoah | 6R | |
| September | 4 | 9/12/2021 | HMA | Daniel Lynch* | 9L | At | VRN | Logan Gilbert | 3L | |
| September | 5 | 9/13/2021 | HMA | Austin Gomber* | 1L | At | VRN | Gerrit Cole | 1R | |
| September | 6 | 9/14/2021 | HMA | Sandy Alcantara | 3R | At | VRN | Freddy Peralta | 1L | |
| September | OFF | 9/15/2021 | ||||||||
| September | 7 | 9/16/2021 | VRN | Zach Eflin | 2L | At | OAK | Dylan Cease | E | |
| September | 8 | 9/17/2021 | VRN | Logan Gilbert | 3L | At | OAK | David Peterson* | 1R | |
| September | 9 | 9/18/2021 | VRN | Trevor Bauer | 3R | At | OAK | Paolo Espino | 1R | |
| September | 10 | 9/19/2021 | VRN | Freddy Peralta | 1L | At | CWC | Danny Duffy* | 4R | |
| September | 11 | 9/20/2021 | VRN | David Price* | 1R | At | CWC | Jon Lester* | 4L | |
| September | 12 | 9/21/2021 | VRN | Zach Eflin | 2L | At | CWC | Jose Berrios | 7R | |
| September | 13 | 9/22/2021 | DYE | Marcus Stroman | 1L | At | VRN | Logan Gilbert | 3L | |
| September | 14 | 9/23/2021 | DYE | Charlie Morton | 2L | At | VRN | Max Scherzer | 1R | |
| September | 15 | 9/24/2021 | DYE | Jack Flaherty | 5L | At | VRN | Freddy Peralta | 1L | |
| September | OFF | 9/25/2021 | ||||||||
| September | 16 | 9/26/2021 | + | VRN | Gerrit Cole | 1R | At | COL | Mike Minor* | E |
| September | 17 | 9/27/2021 | + | VRN | Logan Gilbert | 3L | At | COL | Tyler Mahle | 8L |
| September | 18 | 9/28/2021 | + | VRN | Trevor Bauer | 3R | At | COL | Tarik Skubal* | 3L |
| September | 19 | 9/29/2021 | + | VRN | Freddy Peralta | 1L | At | COL | Clayton Kershaw* | 6L |
| September | 20 | 9/30/2021 | + | VRN | Zach Eflin | 2L | At | COL | Brandon Woodruff | 2L |
| September | 21 | 10/1/2021 | + | JAM | Jordan Montgomery* | 1L | At | VRN | Max Scherzer | 1R |
| September | 22 | 10/2/2021 | + | JAM | Max Fried* | 4R | At | VRN | Gerrit Cole | 1R |
| September | 23 | 10/3/2021 | + | JAM | Robbie Ray* | 1R | At | VRN | Trevor Bauer | 3R |
| September | 24 | 10/4/2021 | + | JAM | Kyle Gibson | 3R | At | VRN | Freddy Peralta | 1L |
| + Indicates In Division Game | ||||||||||