| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2021 | OAK | Martin Perez* | 4L | At | SRD | Chris Paddack | 9L | |
| September | 2 | 9/10/2021 | OAK | Dylan Cease | E | At | SRD | Dylan Bundy | 3L | |
| September | 3 | 9/11/2021 | OAK | David Peterson* | 1R | At | SRD | Dallas Keuchel* | 2R | |
| September | 4 | 9/12/2021 | SRD | Chris Sale* | 9L | At | CWC | Antonio Senzatela | 1R | |
| September | 5 | 9/13/2021 | SRD | Mitch Keller | 2R | At | CWC | Jon Lester* | 4L | |
| September | 6 | 9/14/2021 | SRD | Chris Paddack | 9L | At | CWC | Danny Duffy* | 4R | |
| September | OFF | 9/15/2021 | ||||||||
| September | 7 | 9/16/2021 | + | SRD | Dylan Bundy | 3L | At | GGG | John Gant | E |
| September | 8 | 9/17/2021 | + | SRD | Dallas Keuchel* | 2R | At | GGG | Eduardo Rodriguez* | 1R |
| September | 9 | 9/18/2021 | + | SRD | Yu Darvish | E | At | GGG | Framber Valdez* | 1R |
| September | 10 | 9/19/2021 | + | SRD | Ian Anderson | 2L | At | GGG | Nick Pivetta | E |
| September | 11 | 9/20/2021 | + | SRD | Chris Paddack | 9L | At | GGG | Cole Irvin* | 3R |
| September | 12 | 9/21/2021 | + | TAM | Eli Morgan | 1R | At | SRD | Dylan Bundy | 3L |
| September | 13 | 9/22/2021 | + | TAM | Tyler Glasnow | 2L | At | SRD | Dallas Keuchel* | 2R |
| September | 14 | 9/23/2021 | + | TAM | Trevor Rogers* | 4R | At | SRD | Yu Darvish | E |
| September | 15 | 9/24/2021 | + | TAM | Yusei Kikuchi* | 7L | At | SRD | Ian Anderson | 2L |
| September | OFF | 9/25/2021 | ||||||||
| September | 16 | 9/26/2021 | SRD | Chris Paddack | 9L | At | CUB | Zach Plesac | 4L | |
| September | 17 | 9/27/2021 | SRD | Dylan Bundy | 3L | At | CUB | Alek Manoah | 6R | |
| September | 18 | 9/28/2021 | SRD | Dallas Keuchel* | 2R | At | CUB | Pablo Lopez | E | |
| September | 19 | 9/29/2021 | SRD | Yu Darvish | E | At | HMA | Spencer Howard | 4L | |
| September | 20 | 9/30/2021 | SRD | Chris Sale* | 9L | At | HMA | Austin Gomber* | 1L | |
| September | 21 | 10/1/2021 | SRD | Chris Paddack | 9L | At | HMA | Jesus Luzardo* | 4L | |
| September | 22 | 10/2/2021 | HUC | Tony Santillan | 2R | At | SRD | Dylan Bundy | 3L | |
| September | 23 | 10/3/2021 | HUC | Blake Snell* | 5L | At | SRD | Dallas Keuchel* | 2R | |
| September | 24 | 10/4/2021 | HUC | Zack Greinke | 8L | At | SRD | Yu Darvish | E | |
| + Indicates In Division Game | ||||||||||