| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2021 | CWC | Danny Duffy* | 4R | At | JAM | Kyle Gibson | 3R | |
| September | 2 | 9/10/2021 | CWC | Jose Berrios | 7R | At | JAM | Alex Wood* | 2R | |
| September | 3 | 9/11/2021 | CWC | Shane McClanahan* | 3R | At | JAM | Mitch White | 2R | |
| September | 4 | 9/12/2021 | JAM | Robbie Ray* | 1R | At | OAK | Merrill Kelly | 6L | |
| September | 5 | 9/13/2021 | JAM | Lance Lynn | 4R | At | OAK | Jameson Taillon | E | |
| September | 6 | 9/14/2021 | JAM | Kyle Gibson | 3R | At | OAK | Martin Perez* | 4L | |
| September | OFF | 9/15/2021 | ||||||||
| September | 7 | 9/16/2021 | + | COL | Clayton Kershaw* | 6L | At | JAM | Jordan Montgomery* | 1L |
| September | 8 | 9/17/2021 | + | COL | Vladimir Gutierrez | 2R | At | JAM | Max Fried* | 4R |
| September | 9 | 9/18/2021 | + | COL | Brandon Woodruff | 2L | At | JAM | Lance Lynn | 4R |
| September | 10 | 9/19/2021 | + | COL | Tyler Mahle | 8L | At | JAM | Kyle Gibson | 3R |
| September | 11 | 9/20/2021 | + | COL | Edward Cabrera | 4R | At | JAM | Alex Wood* | 2R |
| September | 12 | 9/21/2021 | + | JAM | Jordan Montgomery* | 1L | At | HUC | Luis Garcia | 7R |
| September | 13 | 9/22/2021 | + | JAM | Max Fried* | 4R | At | HUC | Tony Santillan | 2R |
| September | 14 | 9/23/2021 | + | JAM | Lance Lynn | 4R | At | HUC | Chris Bassitt | 1L |
| September | 15 | 9/24/2021 | + | JAM | Kyle Gibson | 3R | At | HUC | Cal Quantrill | 1L |
| September | OFF | 9/25/2021 | ||||||||
| September | 16 | 9/26/2021 | + | WRK | Kenta Maeda | E | At | JAM | Jordan Montgomery* | 1L |
| September | 17 | 9/27/2021 | + | WRK | Joe Musgrove | 4R | At | JAM | Max Fried* | 4R |
| September | 18 | 9/28/2021 | + | WRK | Julio Urias* | 2R | At | JAM | Robbie Ray* | 1R |
| September | 19 | 9/29/2021 | + | WRK | Matt Manning | 2L | At | JAM | Kyle Gibson | 3R |
| September | 20 | 9/30/2021 | + | WRK | Bailey Ober | 2R | At | JAM | Alex Wood* | 2R |
| September | 21 | 10/1/2021 | + | JAM | Jordan Montgomery* | 1L | At | VRN | Max Scherzer | 1R |
| September | 22 | 10/2/2021 | + | JAM | Max Fried* | 4R | At | VRN | Gerrit Cole | 1R |
| September | 23 | 10/3/2021 | + | JAM | Robbie Ray* | 1R | At | VRN | Trevor Bauer | 3R |
| September | 24 | 10/4/2021 | + | JAM | Kyle Gibson | 3R | At | VRN | Freddy Peralta | 1L |
| + Indicates In Division Game | ||||||||||