| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2021 | HUC | Drew Rasmussen | E | At | BUR | Walker Buehler | E | |
| September | 2 | 9/10/2021 | HUC | Chris Bassitt | 1L | At | BUR | Zack Wheeler | E | |
| September | 3 | 9/11/2021 | HUC | Cal Quantrill | 1L | At | BUR | Adam Wainwright | 1R | |
| September | 4 | 9/12/2021 | AAR | Jacob Degrom | 1R | At | HUC | Zack Greinke | 8L | |
| September | 5 | 9/13/2021 | AAR | Wily Peralta | 8L | At | HUC | Blake Snell* | 5L | |
| September | 6 | 9/14/2021 | AAR | J.T. Brubaker | 2R | At | HUC | Corey Kluber | 6L | |
| September | OFF | 9/15/2021 | ||||||||
| September | 7 | 9/16/2021 | + | HUC | Drew Rasmussen | E | At | WRK | Kenta Maeda | E |
| September | 8 | 9/17/2021 | + | HUC | Chris Bassitt | 1L | At | WRK | Joe Musgrove | 4R |
| September | 9 | 9/18/2021 | + | HUC | Cal Quantrill | 1L | At | WRK | Bailey Ober | 2R |
| September | 10 | 9/19/2021 | + | HUC | Blake Snell* | 5L | At | WRK | Matt Manning | 2L |
| September | 11 | 9/20/2021 | + | HUC | Jordan Holloway | 2L | At | WRK | Julio Urias* | 2R |
| September | 12 | 9/21/2021 | + | JAM | Jordan Montgomery* | 1L | At | HUC | Luis Garcia | 7R |
| September | 13 | 9/22/2021 | + | JAM | Max Fried* | 4R | At | HUC | Tony Santillan | 2R |
| September | 14 | 9/23/2021 | + | JAM | Lance Lynn | 4R | At | HUC | Chris Bassitt | 1L |
| September | 15 | 9/24/2021 | + | JAM | Kyle Gibson | 3R | At | HUC | Cal Quantrill | 1L |
| September | OFF | 9/25/2021 | ||||||||
| September | 16 | 9/26/2021 | HMA | Sandy Alcantara | 3R | At | HUC | Luis Garcia | 7R | |
| September | 17 | 9/27/2021 | HMA | Brady Singer | 1R | At | HUC | Tony Santillan | 2R | |
| September | 18 | 9/28/2021 | HMA | Domingo German | 4L | At | HUC | Blake Snell* | 5L | |
| September | 19 | 9/29/2021 | CUB | Jon Gray | 2L | At | HUC | Zack Greinke | 8L | |
| September | 20 | 9/30/2021 | CUB | Casey Mize | 8R | At | HUC | Cal Quantrill | 1L | |
| September | 21 | 10/1/2021 | CUB | Joe Ross | 5R | At | HUC | Luis Garcia | 7R | |
| September | 22 | 10/2/2021 | HUC | Tony Santillan | 2R | At | SRD | Dylan Bundy | 3L | |
| September | 23 | 10/3/2021 | HUC | Blake Snell* | 5L | At | SRD | Dallas Keuchel* | 2R | |
| September | 24 | 10/4/2021 | HUC | Zack Greinke | 8L | At | SRD | Yu Darvish | E | |
| + Indicates In Division Game | ||||||||||