| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| August | 1 | 8/14/2021 | AAR | Tylor Megill | 9R | At | WRK | Kyle Freeland* | 1R | |
| August | 2 | 8/15/2021 | AAR | Jacob Degrom | 1R | At | WRK | Julio Urias* | 2R | |
| August | 3 | 8/16/2021 | AAR | Steven Matz* | 2R | At | WRK | Joe Musgrove | 4R | |
| August | 4 | 8/17/2021 | WRK | Sean Manaea* | 3L | At | CHI | Wade Miley* | 4L | |
| August | 5 | 8/18/2021 | WRK | Bailey Ober | 2R | At | CHI | Chris Flexen | 4L | |
| August | 6 | 8/19/2021 | WRK | Kyle Freeland* | 1R | At | CHI | John Means* | E | |
| August | OFF | 8/20/2021 | ||||||||
| August | 7 | 8/21/2021 | HOH | Erik Swanson | 1R | At | WRK | Julio Urias* | 2R | |
| August | 8 | 8/22/2021 | HOH | Tyler Anderson* | 1L | At | WRK | Joe Musgrove | 4R | |
| August | 9 | 8/23/2021 | HOH | Logan Webb | 3R | At | WRK | Sean Manaea* | 3L | |
| August | 10 | 8/24/2021 | CRC | Jake Odorizzi | 1R | At | WRK | Bailey Ober | 2R | |
| August | 11 | 8/25/2021 | CRC | Hyun-Jin Ryu* | E | At | WRK | Kyle Freeland* | 1R | |
| August | 12 | 8/26/2021 | CRC | Kevin Gausman | E | At | WRK | Julio Urias* | 2R | |
| August | 13 | 8/27/2021 | WRK | Joe Musgrove | 4R | At | GGG | Cole Irvin* | 3R | |
| August | 14 | 8/28/2021 | WRK | Sean Manaea* | 3L | At | GGG | Framber Valdez* | 1R | |
| August | 15 | 8/29/2021 | WRK | Bailey Ober | 2R | At | GGG | Eduardo Rodriguez* | 1R | |
| August | OFF | 8/30/2021 | ||||||||
| August | 16 | 8/31/2021 | + | WRK | Julio Urias* | 2R | At | HUC | Cal Quantrill | 1L |
| August | 17 | 9/1/2021 | + | WRK | Joe Musgrove | 4R | At | HUC | Luis Garcia | 7R |
| August | 18 | 9/2/2021 | + | WRK | Sean Manaea* | 3L | At | HUC | Jordan Holloway | 2L |
| August | 19 | 9/3/2021 | + | WRK | Bailey Ober | 2R | At | HUC | Blake Snell* | 5L |
| August | 20 | 9/4/2021 | + | WRK | Kyle Freeland* | 1R | At | HUC | Chris Bassitt | 1L |
| August | 21 | 9/5/2021 | + | VRN | Zach Eflin | 2L | At | WRK | Julio Urias* | 2R |
| August | 22 | 9/6/2021 | + | VRN | Trevor Bauer | 3R | At | WRK | Joe Musgrove | 4R |
| August | 23 | 9/7/2021 | + | VRN | Logan Gilbert | 3L | At | WRK | Sean Manaea* | 3L |
| August | 24 | 9/8/2021 | + | VRN | David Price* | 1R | At | WRK | Bailey Ober | 2R |
| + Indicates In Division Game | ||||||||||