| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| August | 1 | 8/14/2021 | NYY | Alex Cobb | 1L | At | VRN | Zach Eflin | 2L | |
| August | 2 | 8/15/2021 | NYY | Corbin Burnes | 2R | At | VRN | David Price* | 1R | |
| August | 3 | 8/16/2021 | NYY | Tanner Houck | 1R | At | VRN | Gerrit Cole | 1R | |
| August | 4 | 8/17/2021 | CRC | Sonny Gray | 1L | At | NYY | Luis Castillo | 1L | |
| August | 5 | 8/18/2021 | CRC | Jake Odorizzi | 1R | At | NYY | Huascar Ynoa | E | |
| August | 6 | 8/19/2021 | CRC | Hyun-Jin Ryu* | E | At | NYY | Alex Cobb | 1L | |
| August | OFF | 8/20/2021 | ||||||||
| August | 7 | 8/21/2021 | + | AAR | Jacob Degrom | 1R | At | NYY | Corbin Burnes | 2R |
| August | 8 | 8/22/2021 | + | AAR | Steven Matz* | 2R | At | NYY | Luis Castillo | 1L |
| August | 9 | 8/23/2021 | + | AAR | Mike Foltynewicz | 2R | At | NYY | Tanner Houck | 1R |
| August | 10 | 8/24/2021 | + | AAR | Shohei Ohtani | 6R | At | NYY | Alex Cobb | 1L |
| August | 11 | 8/25/2021 | + | AAR | Tylor Megill | 9R | At | NYY | Huascar Ynoa | E |
| August | 12 | 8/26/2021 | + | NYY | Corbin Burnes | 2R | At | HMA | Frankie Montas | 1L |
| August | 13 | 8/27/2021 | + | NYY | Luis Castillo | 1L | At | HMA | Daniel Lynch* | 9L |
| August | 14 | 8/28/2021 | + | NYY | Tanner Houck | 1R | At | HMA | Marco Gonzales* | 4L |
| August | 15 | 8/29/2021 | + | NYY | Alex Cobb | 1L | At | HMA | Sandy Alcantara | 3R |
| August | OFF | 8/30/2021 | ||||||||
| August | 16 | 8/31/2021 | + | NYY | Corbin Burnes | 2R | At | OAK | Merrill Kelly | 6L |
| August | 17 | 9/1/2021 | + | NYY | Luis Castillo | 1L | At | OAK | Jameson Taillon | E |
| August | 18 | 9/2/2021 | + | NYY | Tanner Houck | 1R | At | OAK | Michael Pineda | 3R |
| August | 19 | 9/3/2021 | + | NYY | Alex Cobb | 1L | At | OAK | Dylan Cease | E |
| August | 20 | 9/4/2021 | + | NYY | Huascar Ynoa | E | At | OAK | Martin Perez* | 4L |
| August | 21 | 9/5/2021 | + | HMA | Brady Singer | 1R | At | NYY | Corbin Burnes | 2R |
| August | 22 | 9/6/2021 | + | HMA | Frankie Montas | 1L | At | NYY | Luis Castillo | 1L |
| August | 23 | 9/7/2021 | + | HMA | Daniel Lynch* | 9L | At | NYY | Tanner Houck | 1R |
| August | 24 | 9/8/2021 | + | HMA | Marco Gonzales* | 4L | At | NYY | Alex Cobb | 1L |
| + Indicates In Division Game | ||||||||||