| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| August | 1 | 8/14/2021 | HMA | Brady Singer | 1R | At | JAM | Kyle Gibson | 3R | |
| August | 2 | 8/15/2021 | HMA | Frankie Montas | 1L | At | JAM | Max Fried* | 4R | |
| August | 3 | 8/16/2021 | HMA | Daniel Lynch* | 9L | At | JAM | Alex Wood* | 2R | |
| August | 4 | 8/17/2021 | CWC | Johnny Cueto | E | At | HMA | Marco Gonzales* | 4L | |
| August | 5 | 8/18/2021 | CWC | Jose Berrios | 7R | At | HMA | Sandy Alcantara | 3R | |
| August | 6 | 8/19/2021 | CWC | German Marquez | 3R | At | HMA | Brady Singer | 1R | |
| August | OFF | 8/20/2021 | ||||||||
| August | 7 | 8/21/2021 | + | HMA | Frankie Montas | 1L | At | OAK | Paolo Espino | 1R |
| August | 8 | 8/22/2021 | + | HMA | Daniel Lynch* | 9L | At | OAK | David Peterson* | 1R |
| August | 9 | 8/23/2021 | + | HMA | Marco Gonzales* | 4L | At | OAK | Merrill Kelly | 6L |
| August | 10 | 8/24/2021 | + | HMA | Sandy Alcantara | 3R | At | OAK | Jameson Taillon | E |
| August | 11 | 8/25/2021 | + | HMA | Brady Singer | 1R | At | OAK | Michael Pineda | 3R |
| August | 12 | 8/26/2021 | + | NYY | Corbin Burnes | 2R | At | HMA | Frankie Montas | 1L |
| August | 13 | 8/27/2021 | + | NYY | Luis Castillo | 1L | At | HMA | Daniel Lynch* | 9L |
| August | 14 | 8/28/2021 | + | NYY | Tanner Houck | 1R | At | HMA | Marco Gonzales* | 4L |
| August | 15 | 8/29/2021 | + | NYY | Alex Cobb | 1L | At | HMA | Sandy Alcantara | 3R |
| August | OFF | 8/30/2021 | ||||||||
| August | 16 | 8/31/2021 | + | HOH | Nathan Eovaldi | 2L | At | HMA | Brady Singer | 1R |
| August | 17 | 9/1/2021 | + | HOH | Erik Swanson | 1R | At | HMA | Frankie Montas | 1L |
| August | 18 | 9/2/2021 | + | HOH | Logan Webb | 3R | At | HMA | Daniel Lynch* | 9L |
| August | 19 | 9/3/2021 | + | HOH | Ranger Suarez* | 4L | At | HMA | Marco Gonzales* | 4L |
| August | 20 | 9/4/2021 | + | HOH | Tyler Anderson* | 1L | At | HMA | Sandy Alcantara | 3R |
| August | 21 | 9/5/2021 | + | HMA | Brady Singer | 1R | At | NYY | Corbin Burnes | 2R |
| August | 22 | 9/6/2021 | + | HMA | Frankie Montas | 1L | At | NYY | Luis Castillo | 1L |
| August | 23 | 9/7/2021 | + | HMA | Daniel Lynch* | 9L | At | NYY | Tanner Houck | 1R |
| August | 24 | 9/8/2021 | + | HMA | Marco Gonzales* | 4L | At | NYY | Alex Cobb | 1L |
| + Indicates In Division Game | ||||||||||