| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| August | 1 | 8/14/2021 | GGG | John Gant | E | At | CUB | Alek Manoah | 6R | |
| August | 2 | 8/15/2021 | GGG | Garrett Richards | 5L | At | CUB | Joe Ross | 5R | |
| August | 3 | 8/16/2021 | GGG | Nick Pivetta | E | At | CUB | Casey Mize | 8R | |
| August | 4 | 8/17/2021 | COL | Tyler Mahle | 8L | At | GGG | Cole Irvin* | 3R | |
| August | 5 | 8/18/2021 | COL | Mike Minor* | E | At | GGG | Framber Valdez* | 1R | |
| August | 6 | 8/19/2021 | COL | Vladimir Gutierrez | 2R | At | GGG | John Gant | E | |
| August | OFF | 8/20/2021 | ||||||||
| August | 7 | 8/21/2021 | GGG | Nick Pivetta | E | At | CRC | Kevin Gausman | E | |
| August | 8 | 8/22/2021 | GGG | Cole Irvin* | 3R | At | CRC | Triston McKenzie | 1L | |
| August | 9 | 8/23/2021 | GGG | Framber Valdez* | 1R | At | CRC | Sonny Gray | 1L | |
| August | 10 | 8/24/2021 | GGG | Garrett Richards | 5L | At | HOH | Nathan Eovaldi | 2L | |
| August | 11 | 8/25/2021 | GGG | John Gant | E | At | HOH | Zach Thompson | 7R | |
| August | 12 | 8/26/2021 | GGG | Nick Pivetta | E | At | HOH | Erik Swanson | 1R | |
| August | 13 | 8/27/2021 | WRK | Joe Musgrove | 4R | At | GGG | Cole Irvin* | 3R | |
| August | 14 | 8/28/2021 | WRK | Sean Manaea* | 3L | At | GGG | Framber Valdez* | 1R | |
| August | 15 | 8/29/2021 | WRK | Bailey Ober | 2R | At | GGG | Eduardo Rodriguez* | 1R | |
| August | OFF | 8/30/2021 | ||||||||
| August | 16 | 8/31/2021 | + | GGG | John Gant | E | At | SRD | Dylan Bundy | 3L |
| August | 17 | 9/1/2021 | + | GGG | Cole Irvin* | 3R | At | SRD | Ian Anderson | 2L |
| August | 18 | 9/2/2021 | + | GGG | Framber Valdez* | 1R | At | SRD | Yu Darvish | E |
| August | 19 | 9/3/2021 | + | GGG | Eduardo Rodriguez* | 1R | At | SRD | Mitch Keller | 2R |
| August | 20 | 9/4/2021 | + | GGG | Nick Pivetta | E | At | SRD | Chris Paddack | 9L |
| August | 21 | 9/5/2021 | + | DYE | Aaron Nola | 1L | At | GGG | John Gant | E |
| August | 22 | 9/6/2021 | + | DYE | Charlie Morton | 2L | At | GGG | Garrett Richards | 5L |
| August | 23 | 9/7/2021 | + | DYE | Adrian Houser | 5R | At | GGG | Cole Irvin* | 3R |
| August | 24 | 9/8/2021 | + | DYE | Marcus Stroman | 1L | At | GGG | Framber Valdez* | 1R |
| + Indicates In Division Game | ||||||||||