| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| August | 1 | 8/14/2021 | TAM | Jose Urquidy | 5L | At | CRC | Hyun-Jin Ryu* | E | |
| August | 2 | 8/15/2021 | TAM | Johan Oviedo | 2R | At | CRC | Kevin Gausman | E | |
| August | 3 | 8/16/2021 | TAM | Eli Morgan | 1R | At | CRC | Triston McKenzie | 1L | |
| August | 4 | 8/17/2021 | CRC | Sonny Gray | 1L | At | NYY | Luis Castillo | 1L | |
| August | 5 | 8/18/2021 | CRC | Jake Odorizzi | 1R | At | NYY | Huascar Ynoa | E | |
| August | 6 | 8/19/2021 | CRC | Hyun-Jin Ryu* | E | At | NYY | Alex Cobb | 1L | |
| August | OFF | 8/20/2021 | ||||||||
| August | 7 | 8/21/2021 | GGG | Nick Pivetta | E | At | CRC | Kevin Gausman | E | |
| August | 8 | 8/22/2021 | GGG | Cole Irvin* | 3R | At | CRC | Triston McKenzie | 1L | |
| August | 9 | 8/23/2021 | GGG | Framber Valdez* | 1R | At | CRC | Sonny Gray | 1L | |
| August | 10 | 8/24/2021 | CRC | Jake Odorizzi | 1R | At | WRK | Bailey Ober | 2R | |
| August | 11 | 8/25/2021 | CRC | Hyun-Jin Ryu* | E | At | WRK | Kyle Freeland* | 1R | |
| August | 12 | 8/26/2021 | CRC | Kevin Gausman | E | At | WRK | Julio Urias* | 2R | |
| August | 13 | 8/27/2021 | HOH | Ranger Suarez* | 4L | At | CRC | Triston McKenzie | 1L | |
| August | 14 | 8/28/2021 | HOH | Logan Webb | 3R | At | CRC | Sonny Gray | 1L | |
| August | 15 | 8/29/2021 | HOH | Tyler Anderson* | 1L | At | CRC | Jake Odorizzi | 1R | |
| August | OFF | 8/30/2021 | ||||||||
| August | 16 | 8/31/2021 | + | CRC | Hyun-Jin Ryu* | E | At | CUB | Alek Manoah | 6R |
| August | 17 | 9/1/2021 | + | CRC | Kevin Gausman | E | At | CUB | Joe Ross | 5R |
| August | 18 | 9/2/2021 | + | CRC | Triston McKenzie | 1L | At | CUB | Casey Mize | 8R |
| August | 19 | 9/3/2021 | + | CRC | Sonny Gray | 1L | At | CUB | Jon Gray | 2L |
| August | 20 | 9/4/2021 | + | CRC | Jake Odorizzi | 1R | At | CUB | Zach Plesac | 4L |
| August | 21 | 9/5/2021 | + | CWC | German Marquez | 3R | At | CRC | Hyun-Jin Ryu* | E |
| August | 22 | 9/6/2021 | + | CWC | Shane McClanahan* | 3R | At | CRC | Kevin Gausman | E |
| August | 23 | 9/7/2021 | + | CWC | Jose Urena | 6R | At | CRC | Triston McKenzie | 1L |
| August | 24 | 9/8/2021 | + | CWC | Johnny Cueto | E | At | CRC | Sonny Gray | 1L |
| + Indicates In Division Game | ||||||||||