| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| August | 1 | 8/14/2021 | CHI | Ryan Yarbrough* | 4L | At | CWC | German Marquez | 3R | |
| August | 2 | 8/15/2021 | CHI | Jesse Chavez | 1R | At | CWC | Shane McClanahan* | 3R | |
| August | 3 | 8/16/2021 | CHI | Aaron Civale | 4L | At | CWC | Jose Urena | 6R | |
| August | 4 | 8/17/2021 | WRK | Sean Manaea* | 3L | At | CHI | Wade Miley* | 4L | |
| August | 5 | 8/18/2021 | WRK | Bailey Ober | 2R | At | CHI | Chris Flexen | 4L | |
| August | 6 | 8/19/2021 | WRK | Kyle Freeland* | 1R | At | CHI | John Means* | E | |
| August | OFF | 8/20/2021 | ||||||||
| August | 7 | 8/21/2021 | + | TAM | Johan Oviedo | 2R | At | CHI | Jesse Chavez | 1R |
| August | 8 | 8/22/2021 | + | TAM | Eli Morgan | 1R | At | CHI | Aaron Civale | 4L |
| August | 9 | 8/23/2021 | + | TAM | Brad Keller | E | At | CHI | Wade Miley* | 4L |
| August | 10 | 8/24/2021 | + | TAM | Trevor Rogers* | 4R | At | CHI | Chris Flexen | 4L |
| August | 11 | 8/25/2021 | + | TAM | Jose Urquidy | 5L | At | CHI | John Means* | E |
| August | 12 | 8/26/2021 | + | CHI | Jesse Chavez | 1R | At | SRD | Ian Anderson | 2L |
| August | 13 | 8/27/2021 | + | CHI | Aaron Civale | 4L | At | SRD | Yu Darvish | E |
| August | 14 | 8/28/2021 | + | CHI | Wade Miley* | 4L | At | SRD | Mitch Keller | 2R |
| August | 15 | 8/29/2021 | + | CHI | Chris Flexen | 4L | At | SRD | Chris Paddack | 9L |
| August | OFF | 8/30/2021 | ||||||||
| August | 16 | 8/31/2021 | + | CHI | John Means* | E | At | DYE | Aaron Nola | 1L |
| August | 17 | 9/1/2021 | + | CHI | Jesse Chavez | 1R | At | DYE | Charlie Morton | 2L |
| August | 18 | 9/2/2021 | + | CHI | Aaron Civale | 4L | At | DYE | Adrian Houser | 5R |
| August | 19 | 9/3/2021 | + | CHI | Wade Miley* | 4L | At | DYE | Marcus Stroman | 1L |
| August | 20 | 9/4/2021 | + | CHI | Chris Flexen | 4L | At | DYE | Anthony Desclafani | 3R |
| August | 21 | 9/5/2021 | + | SRD | Dylan Bundy | 3L | At | CHI | John Means* | E |
| August | 22 | 9/6/2021 | + | SRD | Dallas Keuchel* | 2R | At | CHI | Jesse Chavez | 1R |
| August | 23 | 9/7/2021 | + | SRD | Yu Darvish | E | At | CHI | Aaron Civale | 4L |
| August | 24 | 9/8/2021 | + | SRD | Mitch Keller | 2R | At | CHI | Wade Miley* | 4L |
| + Indicates In Division Game | ||||||||||