| 2021 Schedule For CUB | ||
| Month | Game | Matchup |
| March | 1 | CUB at AAR |
| March | 2 | CUB at AAR |
| March | 3 | CUB at AAR |
| March | OFF | |
| March | 4 | HUC at CUB |
| March | 5 | HUC at CUB |
| March | 6 | HUC at CUB |
| March | 7 | CUB at TAM |
| March | 8 | CUB at TAM |
| March | 9 | CUB at TAM |
| March | 10 | HOH at CUB |
| March | 11 | HOH at CUB |
| March | 12 | HOH at CUB |
| March | OFF | |
| March | 13 | CUB at COL |
| March | 14 | CUB at COL |
| March | 15 | CUB at COL |
| March | 16 | GGG at CUB |
| March | 17 | GGG at CUB |
| March | 18 | GGG at CUB |
| March | 19 | CUB at HMA |
| March | 20 | CUB at HMA |
| March | 21 | CUB at HMA |
| April | 1 | VRN at CUB |
| April | 2 | VRN at CUB |
| April | 3 | VRN at CUB |
| April | OFF | |
| April | 4 | CUB at CHI |
| April | 5 | CUB at CHI |
| April | 6 | CUB at CHI |
| April | 7 | OAK at CUB |
| April | 8 | OAK at CUB |
| April | 9 | OAK at CUB |
| April | 10 | WRK at CUB |
| April | 11 | WRK at CUB |
| April | 12 | WRK at CUB |
| April | OFF | |
| April | 13 | CUB at SRD |
| April | 14 | CUB at SRD |
| April | 15 | CUB at SRD |
| April | 16 | AAR at CUB |
| April | 17 | AAR at CUB |
| April | 18 | AAR at CUB |
| April | 19 | CUB at HUC |
| April | 20 | CUB at HUC |
| April | 21 | CUB at HUC |
| May | 1 | TAM at CUB |
| May | 2 | TAM at CUB |
| May | 3 | TAM at CUB |
| May | OFF | |
| May | 4 | * CUB at CRC |
| May | 5 | * CUB at CRC |
| May | 6 | * CUB at CRC |
| May | 7 | * CUB at CRC |
| May | 8 | * CUB at CRC |
| May | 9 | * CAL at CUB |
| May | 10 | * CAL at CUB |
| May | 11 | * CAL at CUB |
| May | 12 | * CAL at CUB |
| May | OFF | |
| May | 13 | * BUR at CUB |
| May | 14 | * BUR at CUB |
| May | 15 | * BUR at CUB |
| May | 16 | * BUR at CUB |
| May | 17 | * BUR at CUB |
| May | 18 | * CUB at CAL |
| May | 19 | * CUB at CAL |
| May | 20 | * CUB at CAL |
| May | 21 | * CUB at CAL |
| May | OFF | |
| May | 22 | CUB at HOH |
| May | 23 | CUB at HOH |
| May | 24 | CUB at HOH |
| June | 1 | COL at CUB |
| June | 2 | COL at CUB |
| June | 3 | COL at CUB |
| June | 4 | CUB at GGG |
| June | 5 | CUB at GGG |
| June | 6 | CUB at GGG |
| June | OFF | |
| June | 7 | * CRC at CUB |
| June | 8 | * CRC at CUB |
| June | 9 | * CRC at CUB |
| June | 10 | * CRC at CUB |
| June | 11 | * CRC at CUB |
| June | 12 | * CUB at DUB |
| June | 13 | * CUB at DUB |
| June | 14 | * CUB at DUB |
| June | 15 | * CUB at DUB |
| June | OFF | |
| June | 16 | DYE at CUB |
| June | 17 | DYE at CUB |
| June | 18 | DYE at CUB |
| June | 19 | CUB at SYI |
| June | 20 | CUB at SYI |
| June | 21 | CUB at SYI |
| June | 22 | NYY at CUB |
| June | 23 | NYY at CUB |
| June | 24 | NYY at CUB |
| All Star Break | OFF | |
| All Star Break | OFF | |
| All Star Break | OFF | |
| July | 1 | HMA at CUB |
| July | 2 | HMA at CUB |
| July | 3 | HMA at CUB |
| July | 4 | CUB at VRN |
| July | 5 | CUB at VRN |
| July | 6 | CUB at VRN |
| July | OFF | |
| July | 7 | * CUB at CAL |
| July | 8 | * CUB at CAL |
| July | 9 | * CUB at CAL |
| July | 10 | * CUB at CAL |
| July | 11 | * CUB at CAL |
| July | 12 | * CRC at CUB |
| July | 13 | * CRC at CUB |
| July | 14 | * CRC at CUB |
| July | 15 | * CRC at CUB |
| July | OFF | |
| July | 16 | * CUB at BUR |
| July | 17 | * CUB at BUR |
| July | 18 | * CUB at BUR |
| July | 19 | * CUB at BUR |
| July | 20 | * CUB at BUR |
| July | 21 | * DUB at CUB |
| July | 22 | * DUB at CUB |
| July | 23 | * DUB at CUB |
| July | 24 | * DUB at CUB |
| Trade Deadline | OFF | |
| August | 1 | CHI at CUB |
| August | 2 | CHI at CUB |
| August | 3 | CHI at CUB |
| August | 4 | CUB at OAK |
| August | 5 | CUB at OAK |
| August | 6 | CUB at OAK |
| August | OFF | |
| August | 7 | * CAL at CUB |
| August | 8 | * CAL at CUB |
| August | 9 | * CAL at CUB |
| August | 10 | * CAL at CUB |
| August | 11 | * CAL at CUB |
| August | 12 | * CUB at BUR |
| August | 13 | * CUB at BUR |
| August | 14 | * CUB at BUR |
| August | 15 | * CUB at BUR |
| August | OFF | |
| August | 16 | * DUB at CUB |
| August | 17 | * DUB at CUB |
| August | 18 | * DUB at CUB |
| August | 19 | * DUB at CUB |
| August | 20 | * DUB at CUB |
| August | 21 | * CUB at CRC |
| August | 22 | * CUB at CRC |
| August | 23 | * CUB at CRC |
| August | 24 | * CUB at CRC |
| September | 1 | CUB at WRK |
| September | 2 | CUB at WRK |
| September | 3 | CUB at WRK |
| September | 4 | SRD at CUB |
| September | 5 | SRD at CUB |
| September | 6 | SRD at CUB |
| September | OFF | |
| September | 7 | CUB at DYE |
| September | 8 | CUB at DYE |
| September | 9 | CUB at DYE |
| September | 10 | SYI at CUB |
| September | 11 | SYI at CUB |
| September | 12 | SYI at CUB |
| September | 13 | CUB at NYY |
| September | 14 | CUB at NYY |
| September | 15 | CUB at NYY |
| September | OFF | |
| September | 16 | * CUB at DUB |
| September | 17 | * CUB at DUB |
| September | 18 | * CUB at DUB |
| September | 19 | * CUB at DUB |
| September | 20 | * CUB at DUB |
| September | 21 | * BUR at CUB |
| September | 22 | * BUR at CUB |
| September | 23 | * BUR at CUB |
| September | 24 | * BUR at CUB |