| 2021 Schedule For COL | ||
| Month | Game | Matchup |
| March | 1 | CHI at COL |
| March | 2 | CHI at COL |
| March | 3 | CHI at COL |
| March | OFF | |
| March | 4 | COL at DUB |
| March | 5 | COL at DUB |
| March | 6 | COL at DUB |
| March | 7 | COL at HMA |
| March | 8 | COL at HMA |
| March | 9 | COL at HMA |
| March | 10 | GGG at COL |
| March | 11 | GGG at COL |
| March | 12 | GGG at COL |
| March | OFF | |
| March | 13 | CUB at COL |
| March | 14 | CUB at COL |
| March | 15 | CUB at COL |
| March | 16 | COL at NYY |
| March | 17 | COL at NYY |
| March | 18 | COL at NYY |
| March | 19 | TAM at COL |
| March | 20 | TAM at COL |
| March | 21 | TAM at COL |
| April | 1 | COL at CRC |
| April | 2 | COL at CRC |
| April | 3 | COL at CRC |
| April | OFF | |
| April | 4 | COL at HOH |
| April | 5 | COL at HOH |
| April | 6 | COL at HOH |
| April | 7 | DYE at COL |
| April | 8 | DYE at COL |
| April | 9 | DYE at COL |
| April | 10 | BUR at COL |
| April | 11 | BUR at COL |
| April | 12 | BUR at COL |
| April | OFF | |
| April | 13 | COL at AAR |
| April | 14 | COL at AAR |
| April | 15 | COL at AAR |
| April | 16 | COL at CHI |
| April | 17 | COL at CHI |
| April | 18 | COL at CHI |
| April | 19 | DUB at COL |
| April | 20 | DUB at COL |
| April | 21 | DUB at COL |
| May | 1 | HMA at COL |
| May | 2 | HMA at COL |
| May | 3 | HMA at COL |
| May | OFF | |
| May | 4 | * WRK at COL |
| May | 5 | * WRK at COL |
| May | 6 | * WRK at COL |
| May | 7 | * WRK at COL |
| May | 8 | * WRK at COL |
| May | 9 | * COL at SYI |
| May | 10 | * COL at SYI |
| May | 11 | * COL at SYI |
| May | 12 | * COL at SYI |
| May | OFF | |
| May | 13 | * COL at VRN |
| May | 14 | * COL at VRN |
| May | 15 | * COL at VRN |
| May | 16 | * COL at VRN |
| May | 17 | * COL at VRN |
| May | 18 | * SYI at COL |
| May | 19 | * SYI at COL |
| May | 20 | * SYI at COL |
| May | 21 | * SYI at COL |
| May | OFF | |
| May | 22 | COL at GGG |
| May | 23 | COL at GGG |
| May | 24 | COL at GGG |
| June | 1 | COL at CUB |
| June | 2 | COL at CUB |
| June | 3 | COL at CUB |
| June | 4 | NYY at COL |
| June | 5 | NYY at COL |
| June | 6 | NYY at COL |
| June | OFF | |
| June | 7 | * VRN at COL |
| June | 8 | * VRN at COL |
| June | 9 | * VRN at COL |
| June | 10 | * VRN at COL |
| June | 11 | * VRN at COL |
| June | 12 | * COL at HUC |
| June | 13 | * COL at HUC |
| June | 14 | * COL at HUC |
| June | 15 | * COL at HUC |
| June | OFF | |
| June | 16 | * COL at WRK |
| June | 17 | * COL at WRK |
| June | 18 | * COL at WRK |
| June | 19 | * COL at WRK |
| June | 20 | * COL at WRK |
| June | 21 | * HUC at COL |
| June | 22 | * HUC at COL |
| June | 23 | * HUC at COL |
| June | 24 | * HUC at COL |
| All Star Break | OFF | |
| All Star Break | OFF | |
| All Star Break | OFF | |
| July | 1 | COL at TAM |
| July | 2 | COL at TAM |
| July | 3 | COL at TAM |
| July | 4 | CRC at COL |
| July | 5 | CRC at COL |
| July | 6 | CRC at COL |
| July | OFF | |
| July | 7 | * SYI at COL |
| July | 8 | * SYI at COL |
| July | 9 | * SYI at COL |
| July | 10 | * SYI at COL |
| July | 11 | * SYI at COL |
| July | 12 | * COL at WRK |
| July | 13 | * COL at WRK |
| July | 14 | * COL at WRK |
| July | 15 | * COL at WRK |
| July | OFF | |
| July | 16 | COL at OAK |
| July | 17 | COL at OAK |
| July | 18 | COL at OAK |
| July | 19 | COL at CAL |
| July | 20 | COL at CAL |
| July | 21 | COL at CAL |
| July | 22 | SRD at COL |
| July | 23 | SRD at COL |
| July | 24 | SRD at COL |
| Trade Deadline | OFF | |
| August | 1 | HOH at COL |
| August | 2 | HOH at COL |
| August | 3 | HOH at COL |
| August | 4 | COL at DYE |
| August | 5 | COL at DYE |
| August | 6 | COL at DYE |
| August | OFF | |
| August | 7 | * COL at SYI |
| August | 8 | * COL at SYI |
| August | 9 | * COL at SYI |
| August | 10 | * COL at SYI |
| August | 11 | * COL at SYI |
| August | 12 | * VRN at COL |
| August | 13 | * VRN at COL |
| August | 14 | * VRN at COL |
| August | 15 | * VRN at COL |
| August | OFF | |
| August | 16 | * HUC at COL |
| August | 17 | * HUC at COL |
| August | 18 | * HUC at COL |
| August | 19 | * HUC at COL |
| August | 20 | * HUC at COL |
| August | 21 | * COL at VRN |
| August | 22 | * COL at VRN |
| August | 23 | * COL at VRN |
| August | 24 | * COL at VRN |
| September | 1 | COL at BUR |
| September | 2 | COL at BUR |
| September | 3 | COL at BUR |
| September | 4 | AAR at COL |
| September | 5 | AAR at COL |
| September | 6 | AAR at COL |
| September | OFF | |
| September | 7 | * COL at HUC |
| September | 8 | * COL at HUC |
| September | 9 | * COL at HUC |
| September | 10 | * COL at HUC |
| September | 11 | * COL at HUC |
| September | 12 | * WRK at COL |
| September | 13 | * WRK at COL |
| September | 14 | * WRK at COL |
| September | 15 | * WRK at COL |
| September | OFF | |
| September | 16 | OAK at COL |
| September | 17 | OAK at COL |
| September | 18 | OAK at COL |
| September | 19 | CAL at COL |
| September | 20 | CAL at COL |
| September | 21 | CAL at COL |
| September | 22 | COL at SRD |
| September | 23 | COL at SRD |
| September | 24 | COL at SRD |