| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2018 | TAM | Elieser Hernandez | 4R | At | WRK | Joe Musgrove | 3R | |
| September | 2 | 9/10/2018 | TAM | Shaun Anderson | 1R | At | WRK | Joey Lucchesi* | 2L | |
| September | 3 | 9/11/2018 | TAM | Chris Archer | 1L | At | WRK | Luke Weaver | 4L | |
| September | 4 | 9/12/2018 | WRK | Spencer Turnbull | 3R | At | DUB | Shane Bieber | 1R | |
| September | 5 | 9/13/2018 | WRK | Kyle Gibson | 2R | At | DUB | Dakota Hudson | 3R | |
| September | 6 | 9/14/2018 | WRK | Dinelson Lamet | 1R | At | DUB | Justin Verlander | 2L | |
| September | OFF | 9/15/2018 | ||||||||
| September | 7 | 9/16/2018 | + | WRK | Joey Lucchesi* | 2L | At | SYI | German Marquez | 2R |
| September | 8 | 9/17/2018 | + | WRK | Joe Musgrove | 3R | At | SYI | Charlie Morton | 2R |
| September | 9 | 9/18/2018 | + | WRK | Spencer Turnbull | 3R | At | SYI | James Paxton* | 1L |
| September | 10 | 9/19/2018 | + | WRK | Kenta Maeda | 2R | At | SYI | Danny Duffy* | 2R |
| September | 11 | 9/20/2018 | + | WRK | Dinelson Lamet | 1R | At | SYI | Jose Berrios | E |
| September | 12 | 9/21/2018 | + | COL | Clayton Kershaw* | E | At | WRK | Joey Lucchesi* | 2L |
| September | 13 | 9/22/2018 | + | COL | Kolby Allard* | 3R | At | WRK | Joe Musgrove | 3R |
| September | 14 | 9/23/2018 | + | COL | Andrew Heaney* | 8R | At | WRK | Spencer Turnbull | 3R |
| September | 15 | 9/24/2018 | + | COL | Dylan Bundy | E | At | WRK | Kyle Gibson | 2R |
| September | OFF | 9/25/2018 | ||||||||
| September | 16 | 9/26/2018 | WRK | Joey Lucchesi* | 2L | At | CUB | Julio Teheran | 2L | |
| September | 17 | 9/27/2018 | WRK | Joe Musgrove | 3R | At | CUB | Daniel Norris* | 1R | |
| September | 18 | 9/28/2018 | WRK | Spencer Turnbull | 3R | At | CUB | Jon Gray | 1R | |
| September | 19 | 9/29/2018 | SRD | Jameson Taillon | 3L | At | WRK | Kenta Maeda | 2R | |
| September | 20 | 9/30/2018 | SRD | Chris Sale* | 3L | At | WRK | Dinelson Lamet | 1R | |
| September | 21 | 10/1/2018 | SRD | Adrian Sampson | 7L | At | WRK | Joey Lucchesi* | 2L | |
| September | 22 | 10/2/2018 | WRK | Joe Musgrove | 3R | At | HMA | Sandy Alcantara | 2R | |
| September | 23 | 10/3/2018 | WRK | Spencer Turnbull | 3R | At | HMA | Frankie Montas | E | |
| September | 24 | 10/4/2018 | WRK | Kenta Maeda | 2R | At | HMA | Marcus Stroman | 4R | |
| + Indicates In Division Game | ||||||||||