| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2018 | CUB | Jon Lester* | 6R | At | HUC | Jeremy Hellickson | 4L | |
| September | 2 | 9/10/2018 | CUB | Jake Odorizzi | E | At | HUC | Trevor Cahill | 2R | |
| September | 3 | 9/11/2018 | CUB | Kyle Hendricks | 2L | At | HUC | Blake Snell* | 2L | |
| September | 4 | 9/12/2018 | HUC | Garrett Richards | 2L | At | CHI | Mike Montgomery* | 1L | |
| September | 5 | 9/13/2018 | HUC | Jake Arrieta | 3R | At | CHI | Masahiro Tanaka | 3L | |
| September | 6 | 9/14/2018 | HUC | Jeremy Hellickson | 4L | At | CHI | Kohl Stewart | 1L | |
| September | OFF | 9/15/2018 | ||||||||
| September | 7 | 9/16/2018 | + | SYI | German Marquez | 5R | At | HUC | Corey Kluber | 2R |
| September | 8 | 9/17/2018 | + | SYI | Charlie Morton | 1R | At | HUC | Carlos Carrasco | 1R |
| September | 9 | 9/18/2018 | + | SYI | Jose Berrios | E | At | HUC | Jake Arrieta | 3R |
| September | 10 | 9/19/2018 | + | SYI | James Paxton* | E | At | HUC | Jeremy Hellickson | 4L |
| September | 11 | 9/20/2018 | + | SYI | Chase Anderson | 4L | At | HUC | Corey Kluber | 2R |
| September | 12 | 9/21/2018 | + | HUC | Blake Snell* | 2L | At | WRK | Joe Musgrove | 4R |
| September | 13 | 9/22/2018 | + | HUC | Garrett Richards | 2L | At | WRK | Joey Lucchesi* | 4L |
| September | 14 | 9/23/2018 | + | HUC | Jake Arrieta | 3R | At | WRK | C.C. Sabathia* | 3L |
| September | 15 | 9/24/2018 | + | HUC | Jeremy Hellickson | 4L | At | WRK | Andrew Suarez* | 8L |
| September | OFF | 9/25/2018 | ||||||||
| September | 16 | 9/26/2018 | + | COL | Andrew Heaney* | 4L | At | HUC | Blake Snell* | 2L |
| September | 17 | 9/27/2018 | + | COL | Tyler Mahle | 6R | At | HUC | Garrett Richards | 2L |
| September | 18 | 9/28/2018 | + | COL | Dylan Bundy | 5R | At | HUC | Jake Arrieta | 3R |
| September | 19 | 9/29/2018 | + | COL | James Shields | 5L | At | HUC | Jeremy Hellickson | 4L |
| September | 20 | 9/30/2018 | + | COL | Clayton Kershaw* | 4R | At | HUC | Corey Kluber | 2R |
| September | 21 | 10/1/2018 | + | HUC | Blake Snell* | 2L | At | VRN | Zach Eflin | 4R |
| September | 22 | 10/2/2018 | + | HUC | Garrett Richards | 2L | At | VRN | Max Scherzer | 1R |
| September | 23 | 10/3/2018 | + | HUC | Jake Arrieta | 3R | At | VRN | Cole Hamels* | 1L |
| September | 24 | 10/4/2018 | + | HUC | Jeremy Hellickson | 4L | At | VRN | Gerrit Cole | 6L |
| + Indicates In Division Game | ||||||||||