| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2018 | HMA | Marco Estrada | 3L | At | GGG | Trevor Williams | 3L | |
| September | 2 | 9/10/2018 | HMA | Marcus Stroman | 1L | At | GGG | Mike Foltynewicz | E | |
| September | 3 | 9/11/2018 | HMA | Reynaldo Lopez | 1L | At | GGG | Francisco Liriano* | 7L | |
| September | 4 | 9/12/2018 | GGG | Rick Porcello | 2R | At | COL | Andrew Heaney* | 4L | |
| September | 5 | 9/13/2018 | GGG | Miles Mikolas | 6R | At | COL | James Shields | 5L | |
| September | 6 | 9/14/2018 | GGG | Trevor Williams | 3L | At | COL | Fernando Romero | 2R | |
| September | OFF | 9/15/2018 | ||||||||
| September | 7 | 9/16/2018 | + | GGG | Mike Foltynewicz | E | At | SRD | Dallas Keuchel* | 2R |
| September | 8 | 9/17/2018 | + | GGG | Francisco Liriano* | 7L | At | SRD | Andrew Cashner | E |
| September | 9 | 9/18/2018 | + | GGG | Miles Mikolas | 6R | At | SRD | Homer Bailey | 2R |
| September | 10 | 9/19/2018 | + | GGG | Wade Miley* | E | At | SRD | Ian Kennedy | 2L |
| September | 11 | 9/20/2018 | + | GGG | Trevor Williams | 3L | At | SRD | Dallas Keuchel* | 2R |
| September | 12 | 9/21/2018 | + | TAM | Zack Godley | 1L | At | GGG | Rick Porcello | 2R |
| September | 13 | 9/22/2018 | + | TAM | Jose Quintana* | 1L | At | GGG | Mike Foltynewicz | E |
| September | 14 | 9/23/2018 | + | TAM | Kevin Gausman | 2L | At | GGG | Francisco Liriano* | 7L |
| September | 15 | 9/24/2018 | + | TAM | Luis Severino | 1R | At | GGG | Miles Mikolas | 6R |
| September | OFF | 9/25/2018 | ||||||||
| September | 16 | 9/26/2018 | + | CHI | Luis Cessa | 2L | At | GGG | Trevor Williams | 3L |
| September | 17 | 9/27/2018 | + | CHI | Vince Velasquez | 7R | At | GGG | Mike Foltynewicz | E |
| September | 18 | 9/28/2018 | + | CHI | Masahiro Tanaka | 3L | At | GGG | Rick Porcello | 2R |
| September | 19 | 9/29/2018 | + | CHI | Dylan Covey | 2R | At | GGG | Miles Mikolas | 6R |
| September | 20 | 9/30/2018 | + | CHI | Kohl Stewart | 1L | At | GGG | Francisco Liriano* | 7L |
| September | 21 | 10/1/2018 | + | GGG | Trevor Williams | 3L | At | TAM | Chris Archer | 3R |
| September | 22 | 10/2/2018 | + | GGG | Mike Foltynewicz | E | At | TAM | Luis Severino | 1R |
| September | 23 | 10/3/2018 | + | GGG | Wade Miley* | E | At | TAM | Zack Godley | 1L |
| September | 24 | 10/4/2018 | + | GGG | Miles Mikolas | 6R | At | TAM | Jose Quintana* | 1L |
| + Indicates In Division Game | ||||||||||