| Month | Game | Strat Date | + | Away | Pitcher | Balance | At | Home | Pitcher | Balance |
| September | 1 | 9/9/2018 | COL | Clayton Kershaw* | 4R | At | BUR | Brett Anderson* | 2L | |
| September | 2 | 9/10/2018 | COL | Tyler Mahle | 6R | At | BUR | J.A. Happ* | 6L | |
| September | 3 | 9/11/2018 | COL | Dylan Bundy | 5R | At | BUR | Zack Greinke | 2L | |
| September | 4 | 9/12/2018 | GGG | Rick Porcello | 2R | At | COL | Andrew Heaney* | 4L | |
| September | 5 | 9/13/2018 | GGG | Miles Mikolas | 6R | At | COL | James Shields | 5L | |
| September | 6 | 9/14/2018 | GGG | Trevor Williams | 3L | At | COL | Fernando Romero | 2R | |
| September | OFF | 9/15/2018 | ||||||||
| September | 7 | 9/16/2018 | + | WRK | Joe Musgrove | 4R | At | COL | Clayton Kershaw* | 4R |
| September | 8 | 9/17/2018 | + | WRK | Joey Lucchesi* | 4L | At | COL | Tyler Mahle | 6R |
| September | 9 | 9/18/2018 | + | WRK | C.C. Sabathia* | 3L | At | COL | Dylan Bundy | 5R |
| September | 10 | 9/19/2018 | + | WRK | Andrew Suarez* | 8L | At | COL | James Shields | 5L |
| September | 11 | 9/20/2018 | + | WRK | Luke Weaver | 2R | At | COL | Andrew Heaney* | 4L |
| September | 12 | 9/21/2018 | + | COL | Clayton Kershaw* | 4R | At | SYI | German Marquez | 5R |
| September | 13 | 9/22/2018 | + | COL | Tyler Mahle | 6R | At | SYI | Charlie Morton | 1R |
| September | 14 | 9/23/2018 | + | COL | Dylan Bundy | 5R | At | SYI | Jose Berrios | E |
| September | 15 | 9/24/2018 | + | COL | James Shields | 5L | At | SYI | James Paxton* | E |
| September | OFF | 9/25/2018 | ||||||||
| September | 16 | 9/26/2018 | + | COL | Andrew Heaney* | 4L | At | HUC | Blake Snell* | 2L |
| September | 17 | 9/27/2018 | + | COL | Tyler Mahle | 6R | At | HUC | Garrett Richards | 2L |
| September | 18 | 9/28/2018 | + | COL | Dylan Bundy | 5R | At | HUC | Jake Arrieta | 3R |
| September | 19 | 9/29/2018 | + | COL | James Shields | 5L | At | HUC | Jeremy Hellickson | 4L |
| September | 20 | 9/30/2018 | + | COL | Clayton Kershaw* | 4R | At | HUC | Corey Kluber | 2R |
| September | 21 | 10/1/2018 | + | SYI | German Marquez | 5R | At | COL | Andrew Heaney* | 4L |
| September | 22 | 10/2/2018 | + | SYI | Chase Anderson | 4L | At | COL | Tyler Mahle | 6R |
| September | 23 | 10/3/2018 | + | SYI | Charlie Morton | 1R | At | COL | Dylan Bundy | 5R |
| September | 24 | 10/4/2018 | + | SYI | Jose Berrios | E | At | COL | James Shields | 5L |
| + Indicates In Division Game | ||||||||||