| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | AAR | CC Sabathia* | At | TAM | Kevin Gausman | |
| September | 2 | AAR | Mike Fiers | At | TAM | Jose Quintana* | |
| September | 3 | AAR | Jacob Degrom | At | TAM | Zack Godley | |
| September | 4 | TAM | Luis Severino | At | SYI | Kendall Graveman | |
| September | 5 | TAM | Jason Hammel | At | SYI | Chase Anderson | |
| September | 6 | TAM | Kevin Gausman | At | SYI | Charlie Morton | |
| September | OFF | ||||||
| September | 7 | + | GGG | Martin Perez* | At | TAM | Chris Archer |
| September | 8 | + | GGG | Mike Foltynewicz | At | TAM | Zack Godley |
| September | 9 | + | GGG | Rick Porcello | At | TAM | Luis Severino |
| September | 10 | + | GGG | Trevor Williams | At | TAM | Jason Hammel |
| September | 11 | + | GGG | Reynaldo Lopez | At | TAM | Kevin Gausman |
| September | 12 | + | TAM | Chris Archer | At | SRD | Chris Sale* |
| September | 13 | + | TAM | Zack Godley | At | SRD | Francisco Liriano* |
| September | 14 | + | TAM | Luis Severino | At | SRD | Yu Darvish |
| September | 15 | + | TAM | Jose Quintana* | At | SRD | Alex Wood* |
| September | OFF | ||||||
| September | 16 | + | CHI | Masahiro Tanaka | At | TAM | Chris Archer |
| September | 17 | + | CHI | Ben Lively | At | TAM | Zack Godley |
| September | 18 | + | CHI | Jeff Samardzija | At | TAM | Luis Severino |
| September | 19 | + | CHI | Dinelson Lamet | At | TAM | Jose Quintana* |
| September | 20 | + | CHI | Austin Bibens-Dirkx | At | TAM | Jason Hammel |
| September | 21 | + | TAM | Chris Archer | At | DYE | Scott Feldman |
| September | 22 | + | TAM | Zack Godley | At | DYE | Felix Hernandez |
| September | 23 | + | TAM | Kevin Gausman | At | DYE | Josh Tomlin |
| September | 24 | + | TAM | Jose Quintana* | At | DYE | Luis Perdomo |
| + Indicates In Division Game | |||||||