| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | BZZ | Andrew Cashner | At | SRD | Michael Pineda | |
| September | 2 | BZZ | Lance Lynn | At | SRD | Dallas Keuchel* | |
| September | 3 | BZZ | Jason Vargas* | At | SRD | Francisco Liriano* | |
| September | 4 | SRD | Randall Delgado | At | HUC | Corey Kluber | |
| September | 5 | SRD | Yu Darvish | At | HUC | Carlos Carrasco | |
| September | 6 | SRD | Rafael Montero | At | HUC | Chris Stratton | |
| September | OFF | ||||||
| September | 7 | + | SRD | Chris Sale* | At | CHI | Jeff Samardzija |
| September | 8 | + | SRD | Francisco Liriano* | At | CHI | Ben Lively |
| September | 9 | + | SRD | Yu Darvish | At | CHI | Robbie Ray* |
| September | 10 | + | SRD | Alex Wood* | At | CHI | Dinelson Lamet |
| September | 11 | + | SRD | Rafael Montero | At | CHI | Masahiro Tanaka |
| September | 12 | + | TAM | Chris Archer | At | SRD | Chris Sale* |
| September | 13 | + | TAM | Zack Godley | At | SRD | Francisco Liriano* |
| September | 14 | + | TAM | Luis Severino | At | SRD | Yu Darvish |
| September | 15 | + | TAM | Jose Quintana* | At | SRD | Alex Wood* |
| September | OFF | ||||||
| September | 16 | SRD | Dallas Keuchel* | At | SYI | James Paxton* | |
| September | 17 | SRD | Francisco Liriano* | At | SYI | Charlie Morton | |
| September | 18 | SRD | Yu Darvish | At | SYI | German Marquez | |
| September | 19 | OAK | Matt Boyd* | At | SRD | Alex Wood* | |
| September | 20 | OAK | Jameson Taillon | At | SRD | Carson Fulmer | |
| September | 21 | OAK | Dan Straily | At | SRD | Rafael Montero | |
| September | 22 | SRD | Francisco Liriano* | At | BUR | Drew Pomeranz* | |
| September | 23 | SRD | Yu Darvish | At | BUR | Zach Davies | |
| September | 24 | SRD | Alex Wood* | At | BUR | Lance McCullers | |
| + Indicates In Division Game | |||||||