| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | HUC | Chris Stratton | At | BUR | Lance McCullers | |
| September | 2 | HUC | Blake Snell* | At | BUR | Drew Pomeranz* | |
| September | 3 | HUC | Jake Arrieta | At | BUR | Taijuan Walker | |
| September | 4 | SRD | Randall Delgado | At | HUC | Corey Kluber | |
| September | 5 | SRD | Yu Darvish | At | HUC | Carlos Carrasco | |
| September | 6 | SRD | Rafael Montero | At | HUC | Chris Stratton | |
| September | OFF | ||||||
| September | 7 | HUC | Jake Arrieta | At | DYE | Andrew Triggs | |
| September | 8 | HUC | Corey Kluber | At | DYE | Ivan Nova | |
| September | 9 | HUC | Blake Snell* | At | DYE | Josh Tomlin | |
| September | 10 | HUC | Chris Stratton | At | CAL | Matt Moore* | |
| September | 11 | HUC | Carlos Carrasco | At | CAL | Adalberto Mejia* | |
| September | 12 | HUC | Jake Arrieta | At | CAL | Sean Newcomb* | |
| September | 13 | AAR | Jacob Degrom | At | HUC | Corey Kluber | |
| September | 14 | AAR | Jordan Zimmermann | At | HUC | Blake Snell* | |
| September | 15 | AAR | Ricky Nolasco | At | HUC | Jon Lester* | |
| September | OFF | ||||||
| September | 16 | + | HUC | Carlos Carrasco | At | VRN | Chad Kuhl |
| September | 17 | + | HUC | Jake Arrieta | At | VRN | Brandon Woodruff |
| September | 18 | + | HUC | Corey Kluber | At | VRN | Sal Romano |
| September | 19 | + | HUC | Blake Snell* | At | VRN | Robert Gsellman |
| September | 20 | + | HUC | Jon Lester* | At | VRN | R.A. Dickey |
| September | 21 | + | WRK | Jordan Montgomery* | At | HUC | Carlos Carrasco |
| September | 22 | + | WRK | Jimmy Nelson | At | HUC | Jake Arrieta |
| September | 23 | + | WRK | Sean Manaea* | At | HUC | Corey Kluber |
| September | 24 | + | WRK | Jaime Garcia* | At | HUC | Blake Snell* |
| + Indicates In Division Game | |||||||