| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | CHI | Dinelson Lamet | At | HMA | J.A. Happ* | |
| September | 2 | CHI | Robbie Ray* | At | HMA | Marcus Stroman | |
| September | 3 | CHI | Jeff Samardzija | At | HMA | Gerrit Cole | |
| September | 4 | HMA | Marco Estrada | At | CUB | Kyle Hendricks | |
| September | 5 | HMA | Tanner Roark | At | CUB | Jeremy Hellickson | |
| September | 6 | HMA | J.A. Happ* | At | CUB | Jon Gray | |
| September | OFF | ||||||
| September | 7 | + | HMA | Marcus Stroman | At | BZZ | Lance Lynn |
| September | 8 | + | HMA | Gerrit Cole | At | BZZ | Mike Leake |
| September | 9 | + | HMA | Marco Estrada | At | BZZ | Jason Vargas* |
| September | 10 | + | HMA | Tanner Roark | At | BZZ | Edinson Volquez |
| September | 11 | + | HMA | J.A. Happ* | At | BZZ | Andrew Cashner |
| September | 12 | + | NYY | Jhoulys Chacin | At | HMA | Marcus Stroman |
| September | 13 | + | NYY | Paul Blackburn | At | HMA | Gerrit Cole |
| September | 14 | + | NYY | Carlos Martinez | At | HMA | Marco Estrada |
| September | 15 | + | NYY | Trevor Bauer | At | HMA | Tanner Roark |
| September | OFF | ||||||
| September | 16 | + | AAR | Noah Syndergaard | At | HMA | Matt Cain |
| September | 17 | + | AAR | Mike Fiers | At | HMA | Marcus Stroman |
| September | 18 | + | AAR | Jacob Degrom | At | HMA | Gerrit Cole |
| September | 19 | + | AAR | Jordan Zimmermann | At | HMA | Marco Estrada |
| September | 20 | + | AAR | Ricky Nolasco | At | HMA | Tanner Roark |
| September | 21 | + | HMA | Matt Cain | At | NYY | Alex Cobb |
| September | 22 | + | HMA | Brandon McCarthy | At | NYY | Jhoulys Chacin |
| September | 23 | + | HMA | Gerrit Cole | At | NYY | Paul Blackburn |
| September | 24 | + | HMA | Marco Estrada | At | NYY | Carlos Martinez |
| + Indicates In Division Game | |||||||