| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | DYE | Aaron Nola | At | OAK | Matt Boyd* | |
| September | 2 | DYE | Josh Tomlin | At | OAK | Jameson Taillon | |
| September | 3 | DYE | Felix Hernandez | At | OAK | Dan Straily | |
| September | 4 | WRK | Jaime Garcia* | At | DYE | Ivan Nova | |
| September | 5 | WRK | Kyle Gibson | At | DYE | Daniel Mengden | |
| September | 6 | WRK | Jordan Montgomery* | At | DYE | Aaron Nola | |
| September | OFF | ||||||
| September | 7 | HUC | Jake Arrieta | At | DYE | Andrew Triggs | |
| September | 8 | HUC | Corey Kluber | At | DYE | Ivan Nova | |
| September | 9 | HUC | Blake Snell* | At | DYE | Josh Tomlin | |
| September | 10 | DYE | Aaron Nola | At | AAR | Ricky Nolasco | |
| September | 11 | DYE | Felix Hernandez | At | AAR | Noah Syndergaard | |
| September | 12 | DYE | Andrew Triggs | At | AAR | Mike Fiers | |
| September | 13 | CAL | Clayton Richard* | At | DYE | Ivan Nova | |
| September | 14 | CAL | Patrick Corbin* | At | DYE | Josh Tomlin | |
| September | 15 | CAL | Matt Moore* | At | DYE | Aaron Nola | |
| September | OFF | ||||||
| September | 16 | + | DYE | Daniel Mengden | At | GGG | Reynaldo Lopez |
| September | 17 | + | DYE | Ivan Nova | At | GGG | Trevor Williams |
| September | 18 | + | DYE | Andrew Triggs | At | GGG | Martin Perez* |
| September | 19 | + | DYE | Luis Perdomo | At | GGG | Brent Suter* |
| September | 20 | + | DYE | Aaron Nola | At | GGG | Rick Porcello |
| September | 21 | + | TAM | Chris Archer | At | DYE | Scott Feldman |
| September | 22 | + | TAM | Zack Godley | At | DYE | Felix Hernandez |
| September | 23 | + | TAM | Kevin Gausman | At | DYE | Josh Tomlin |
| September | 24 | + | TAM | Jose Quintana* | At | DYE | Luis Perdomo |
| + Indicates In Division Game | |||||||