| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | COL | Cole Hamels* | At | DUB | Jerad Eickhoff | |
| September | 2 | COL | Mike Montgomery* | At | DUB | Justin Verlander | |
| September | 3 | COL | Dylan Bundy | At | DUB | John Lackey | |
| September | 4 | GGG | Rick Porcello | At | COL | Clayton Kershaw* | |
| September | 5 | GGG | Trevor Williams | At | COL | Ervin Santana | |
| September | 6 | GGG | Reynaldo Lopez | At | COL | Cole Hamels* | |
| September | OFF | ||||||
| September | 7 | + | SYI | Jose Berrios | At | COL | Mike Montgomery* |
| September | 8 | + | SYI | German Marquez | At | COL | Clayton Kershaw* |
| September | 9 | + | SYI | Danny Duffy* | At | COL | Dylan Bundy |
| September | 10 | + | SYI | Kendall Graveman | At | COL | Cole Hamels* |
| September | 11 | + | SYI | James Paxton* | At | COL | Ervin Santana |
| September | 12 | + | COL | Mike Montgomery* | At | VRN | Brandon Woodruff |
| September | 13 | + | COL | Erasmo Ramirez | At | VRN | Sal Romano |
| September | 14 | + | COL | Dylan Bundy | At | VRN | Robert Gsellman |
| September | 15 | + | COL | Clayton Kershaw* | At | VRN | R.A. Dickey |
| September | OFF | ||||||
| September | 16 | + | COL | Ervin Santana | At | WRK | Jordan Montgomery* |
| September | 17 | + | COL | Cole Hamels* | At | WRK | Jimmy Nelson |
| September | 18 | + | COL | Mike Montgomery* | At | WRK | Sean Manaea* |
| September | 19 | + | COL | Erasmo Ramirez | At | WRK | Jaime Garcia* |
| September | 20 | + | COL | Junior Guerra | At | WRK | Julio Urias* |
| September | 21 | + | VRN | Chad Kuhl | At | COL | Dylan Bundy |
| September | 22 | + | VRN | Brandon Woodruff | At | COL | Ervin Santana |
| September | 23 | + | VRN | Sal Romano | At | COL | Mike Montgomery* |
| September | 24 | + | VRN | Robert Gsellman | At | COL | James Shields |
| + Indicates In Division Game | |||||||