| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| August | 1 | SRD | Francisco Liriano* | At | WRK | Jimmy Nelson | |
| August | 2 | SRD | Rafael Montero | At | WRK | Sean Manaea* | |
| August | 3 | SRD | Yu Darvish | At | WRK | Kyle Gibson | |
| August | 4 | CAL | Ty Blach* | At | SRD | Michael Pineda | |
| August | 5 | CAL | Matt Moore* | At | SRD | Dallas Keuchel* | |
| August | 6 | CAL | Zack Wheeler | At | SRD | Francisco Liriano* | |
| August | OFF | ||||||
| August | 7 | + | SRD | Rafael Montero | At | DYE | Andrew Triggs |
| August | 8 | + | SRD | Yu Darvish | At | DYE | Ivan Nova |
| August | 9 | + | SRD | Michael Pineda | At | DYE | Luis Perdomo |
| August | 10 | + | SRD | Dallas Keuchel* | At | DYE | Josh Tomlin |
| August | 11 | + | SRD | Francisco Liriano* | At | DYE | Scott Feldman |
| August | 12 | + | GGG | Trevor Williams | At | SRD | Chris Sale* |
| August | 13 | + | GGG | Rick Porcello | At | SRD | Yu Darvish |
| August | 14 | + | GGG | Martin Perez* | At | SRD | Alex Wood* |
| August | 15 | + | GGG | Mike Foltynewicz | At | SRD | Dallas Keuchel* |
| August | OFF | ||||||
| August | 16 | + | CHI | Robbie Ray* | At | SRD | Francisco Liriano* |
| August | 17 | + | CHI | Tyler Anderson* | At | SRD | Rafael Montero |
| August | 18 | + | CHI | Austin Bibens-Dirkx | At | SRD | Chris Sale* |
| August | 19 | + | CHI | Jeff Samardzija | At | SRD | Yu Darvish |
| August | 20 | + | CHI | Masahiro Tanaka | At | SRD | Alex Wood* |
| August | 21 | + | SRD | Dallas Keuchel* | At | GGG | Joe Ross |
| August | 22 | + | SRD | Francisco Liriano* | At | GGG | Trevor Williams |
| August | 23 | + | SRD | Chris Sale* | At | GGG | Rick Porcello |
| August | 24 | + | SRD | Yu Darvish | At | GGG | Martin Perez* |
| + Indicates In Division Game | |||||||