| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| August | 1 | TAM | Jason Hammel | At | COL | Clayton Kershaw* | |
| August | 2 | TAM | Kevin Gausman | At | COL | Ervin Santana | |
| August | 3 | TAM | Chris Archer | At | COL | Mike Montgomery* | |
| August | 4 | COL | Dylan Bundy | At | HMA | Brandon McCarthy | |
| August | 5 | COL | Erasmo Ramirez | At | HMA | J.A. Happ* | |
| August | 6 | COL | James Shields | At | HMA | Marcus Stroman | |
| August | OFF | ||||||
| August | 7 | CHI | Tyler Anderson* | At | COL | Cole Hamels* | |
| August | 8 | CHI | Austin Bibens-Dirkx | At | COL | Clayton Kershaw* | |
| August | 9 | CHI | Masahiro Tanaka | At | COL | Ervin Santana | |
| August | 10 | CUB | Adam Wainwright | At | COL | Dylan Bundy | |
| August | 11 | CUB | Julio Teheran | At | COL | Erasmo Ramirez | |
| August | 12 | CUB | Jake Odorizzi | At | COL | James Shields | |
| August | 13 | COL | Cole Hamels* | At | NYY | Carlos Martinez | |
| August | 14 | COL | Clayton Kershaw* | At | NYY | Trevor Bauer | |
| August | 15 | COL | Ervin Santana | At | NYY | Matt Shoemaker | |
| August | OFF | ||||||
| August | 16 | + | COL | Mike Montgomery* | At | SYI | Kendall Graveman |
| August | 17 | + | COL | Dylan Bundy | At | SYI | German Marquez |
| August | 18 | + | COL | Clayton Kershaw* | At | SYI | Danny Duffy* |
| August | 19 | + | COL | Ervin Santana | At | SYI | Chase Anderson |
| August | 20 | + | COL | Cole Hamels* | At | SYI | James Paxton* |
| August | 21 | + | HUC | Jake Arrieta | At | COL | Mike Montgomery* |
| August | 22 | + | HUC | Corey Kluber | At | COL | Dylan Bundy |
| August | 23 | + | HUC | Carlos Carrasco | At | COL | Clayton Kershaw* |
| August | 24 | + | HUC | Jon Lester* | At | COL | Ervin Santana |
| + Indicates In Division Game | |||||||