| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | COL | Josh Tomlin | At | CUB | Brandon Finnegan* | |
| September | 2 | COL | Clayton Kershaw* | At | CUB | Jon Gray | |
| September | 3 | COL | Cole Hamels* | At | CUB | Kyle Hendricks | |
| September | 4 | TAM | Mat Latos | At | COL | Matt Wisler | |
| September | 5 | TAM | Jason Hammel | At | COL | Steven Wright | |
| September | 6 | TAM | Steven Matz* | At | COL | Josh Tomlin | |
| September | OFF | ||||||
| September | 7 | COL | Cole Hamels* | At | CHI | Jeff Samardzija | |
| September | 8 | COL | Mike Montgomery* | At | CHI | Tyler Chatwood | |
| September | 9 | COL | Joe Ross | At | CHI | Robbie Ray* | |
| September | 10 | BUR | Wade Miley* | At | COL | Matt Wisler | |
| September | 11 | BUR | Taijuan Walker | At | COL | Ervin Santana | |
| September | 12 | BUR | Drew Pomeranz* | At | COL | Josh Tomlin | |
| September | 13 | COL | Steven Wright | At | OAK | Eduardo Rodriguez* | |
| September | 14 | COL | Joe Ross | At | OAK | Christian Friedrich* | |
| September | 15 | COL | Matt Wisler | At | OAK | Matt Garza | |
| September | OFF | ||||||
| September | 16 | + | COL | Josh Tomlin | At | HUC | Carlos Carrasco |
| September | 17 | + | COL | Ervin Santana | At | HUC | Jake Arrieta |
| September | 18 | + | COL | Joe Ross | At | HUC | Corey Kluber |
| September | 19 | + | COL | Matt Wisler | At | HUC | Nathan Karns |
| September | 20 | + | COL | Steven Wright | At | HUC | Hisashi Iwakuma |
| September | 21 | + | SYI | Kendall Graveman | At | COL | Josh Tomlin |
| September | 22 | + | SYI | Adam Conley* | At | COL | Ervin Santana |
| September | 23 | + | SYI | Drew Smyly* | At | COL | Joe Ross |
| September | 24 | + | SYI | James Paxton* | At | COL | Matt Wisler |
| + Indicates In Division Game | |||||||