| Month | Game | + | Away | Pitcher | At | Home | Pitcher |
| September | 1 | CAL | Clay Buchholz | At | SYI | Kendall Graveman | |
| September | 2 | CAL | Jeremy Hellickson | At | SYI | Tim Adleman | |
| September | 3 | CAL | James Shields | At | SYI | Drew Smyly* | |
| September | 4 | NYY | Carlos Martinez | At | CAL | Matt Moore* | |
| September | 5 | NYY | Matt Shoemaker | At | CAL | Patrick Corbin* | |
| September | 6 | NYY | Tom Koehler | At | CAL | Andrew Cashner | |
| September | OFF | ||||||
| September | 7 | + | CAL | Jeremy Hellickson | At | DUB | Justin Verlander |
| September | 8 | + | CAL | James Shields | At | DUB | Rich Hill* |
| September | 9 | + | CAL | Tyler Duffey | At | DUB | Jerad Eickhoff |
| September | 10 | + | CAL | Matt Moore* | At | DUB | John Lackey |
| September | 11 | + | CAL | Patrick Corbin* | At | DUB | Justin Verlander |
| September | 12 | + | CUB | Yordano Ventura | At | CAL | Jeremy Hellickson |
| September | 13 | + | CUB | Kyle Hendricks | At | CAL | James Shields |
| September | 14 | + | CUB | Jake Odorizzi | At | CAL | Matt Moore* |
| September | 15 | + | CUB | Julio Teheran | At | CAL | Tyler Duffey |
| September | OFF | ||||||
| September | 16 | AAR | Jacob Degrom | At | CAL | Andrew Cashner | |
| September | 17 | AAR | Chase Anderson | At | CAL | Jeremy Hellickson | |
| September | 18 | AAR | Noah Syndergaard | At | CAL | James Shields | |
| September | 19 | WRK | Ricky Nolasco | At | CAL | Patrick Corbin* | |
| September | 20 | WRK | Sean Manaea* | At | CAL | Matt Moore* | |
| September | 21 | WRK | Mike Foltynewicz | At | CAL | Tyler Duffey | |
| September | 22 | CAL | Jeremy Hellickson | At | TAM | Chris Archer | |
| September | 23 | CAL | James Shields | At | TAM | Jason Hammel | |
| September | 24 | CAL | Patrick Corbin* | At | TAM | Kevin Gausman | |
| + Indicates In Division Game | |||||||